应用化学2025，Vol.42Issue(6)：741-756,16.DOI:10.19894/j.issn.1000-0518.250010
聚集诱导发光分子用于荧光成像治疗研究进展
Research Progress of Aggregation-Induced Emission Molecules for Fluorescence Imaging Therapy
王振操 1吕宁 1陈梁芳 1饶跃峰1
作者信息
- 1. 浙江大学医学院附属第一医院临床药学部,杭州 310003
- 折叠
摘要
Abstract
Aggregation-induced emission(AIE)molecules have been widely used in research fields such as bioimaging and biotherapy due to their easy modification,strong resistance to photobleaching,high fluorescence imaging signal-to-noise ratio,and good biocompatibility.Based on these characteristics,AIE molecules have been developed as disease diagnostic agents that can specifically recognize the environmental signals of lesion areas,thereby aggregating in the disease area and generating bright fluorescence signals to locate the lesion site.This approach can visualize the lesion in situ in real time and has attracted much attention.In addition,on the basis of imaging diagnosis,the therapeutic capabilities of AIE molecules have been further developed and can be used as photothermal therapy agents,photodynamic therapy agents,etc.,promoting the rapid development of the field of imaging diagnosis combined with phototherapy.Therefore,this article reviews the research progress of AIE molecule-targeted imaging combined with phototherapy in recent years(2020-2024),and discusses in detail the relationship between the molecular structure design and fluorescence imaging and phototherapy effects,hoping to bring new ideas to the development of photodiagnosis and therapy.关键词
聚集诱导发光/光动力治疗/光热治疗/成像协同治疗Key words
Aggregation-induced emission/Photodynamics therapy/Photothermal therapy/Imaging collaborative therapy分类
化学引用本文复制引用
王振操,吕宁,陈梁芳,饶跃峰..聚集诱导发光分子用于荧光成像治疗研究进展[J].应用化学,2025,42(6):741-756,16.
