中国比较医学杂志2025，Vol.35Issue(5)：131-138,8.DOI:10.3969/j.issn.1671-7856.2025.05.013
铜代谢在肿瘤免疫中的作用及其靶向治疗策略
Role of copper metabolism in tumor development and tumor immunity
摘要
Abstract
Copper is an indispensable trace element that participates in numerous metabolic and signaling processes in both its oxidized and reduced states.It is intimately associated with several facets of tumor development,and alterations in copper homeostasis can substantially influence processes such as tumor cell growth,metastasis,modulation of the tumor microenvironment,oxidative stress,cell signaling,and the evasion of tumor cells from immune surveillance.Copper metabolism in tumor cells predominantly promotes immune escape by regulating the expression of programmed death ligand 1.In view of its crucial role in tumor immunity,modulating copper metabolism has emerged as a prospective therapeutic approach.This paper reviews the regulatory mechanisms of copper within the human body and investigates how disruptions to copper metabolism impact tumorigenesis and progression,along with the immune and tumor microenvironments.We also discuss the research value of copper as a target for tumor immunotherapy,thus providing a theoretical basis for future research and clinical applications.关键词
铜/铜代谢/铜死亡/肿瘤免疫Key words
copper/copper metabolism/copper death/tumor immunity引用本文复制引用
付励严,辛庆瑄,岳保红..铜代谢在肿瘤免疫中的作用及其靶向治疗策略[J].中国比较医学杂志,2025,35(5):131-138,8.基金项目
河南省科技攻关资助项目(232102310140) （232102310140）
中国博士后科学基金(2021M692929). （2021M692929）
