中国比较医学杂志2025，Vol.35Issue(5)：139-154,16.DOI:10.3969/j.issn.1671-7856.2025.05.014
基于信号通路探讨骨肉瘤的发病机制及中药干预研究进展
Research progress on the pathogenesis and traditional Chinese medicine intervention of osteosarcoma based on signaling pathways
摘要
Abstract
Osteosarcoma(OS)is a common primary malignant bone tumor with high mortality,disability,metastasis,and recurrence rates and a complex pathogenesis,Resulting in serious effects on patient quality of life and huge economic burdens on families and society.Traditional Chinese medicine(TCM)has"multi-target,multi-component and multi-pathway"characteristics.Recent studies using animal and cell models demonstrated that the mechanism of OS progression was related to Notch,mitogen-activated protein kinase,Wnt/β-catenin,phosphatidylinositol 3-kinase/AKT,Hedgehog and nuclear factor-κB,transforming growth factor-β/Smad and signal transducer and activator of transcription pathways.TCM can exert anti-tumor effects by influencing biological processes such as cell proliferation,migration,invasion,apoptosis,and autophagy via interfering with the above signaling pathways.This review considers the roles of these signaling pathways in OS and summarizes the current research status of TCM interventions in the prevention and treatment of OS,with the aim of providing a reference for future studies of TCM treatments of OS and to provide new ideas for its clinical treatment.关键词
天然药物/信号通路/靶点/中药/骨肉瘤Key words
natural medicine/signaling pathways/target/traditional Chinese medicine/osteosarcoma引用本文复制引用
周海东,卢姚宏,胡梁深,龚礼,谢杰飞,胡文涛,单记春,范少勇..基于信号通路探讨骨肉瘤的发病机制及中药干预研究进展[J].中国比较医学杂志,2025,35(5):139-154,16.基金项目
江西省重点研发计划(20202BBG73028) （20202BBG73028）
2024年江西省校级大学生创新创业训练计划(202410412281) （202410412281）
2024年江西省研究生创新专项资金(YC2024-B239). （YC2024-B239）
