中国人兽共患病学报2025，Vol.41Issue(5)：515-521,7.DOI:10.3969/j.issn.1002-2694.2025.00.075
基于GenBank分析1995-2023年间亚洲地区及俄罗斯诺如病毒基因型别分布和变迁
Analysis of the genotype distribution and changes in norovirus in Asia and Russia in GenBank from 1995 to 2023
摘要
Abstract
An analysis of 24 144 norovirus sequences from Asia and Russia deposited in GenBank between 1995 and 2023 was conducted,to understand the temporal and spatial variations in norovirus genotypes in these regions.Norovirus sequences from Asia and Russia were downloaded in FASTA format from GenBank for the years 1995-2023,and analyzed in Excel,R language,and GraphPad Prism for data visualization.The number of norovirus sequences submitted to GenBank increased annually from 2004 and peaked in 2015.Notably,China and Japan contributed 62.3％of all submitted norovirus sequences.These sequences encompassed 31 capsid genotypes(C-type),with GⅠ accounting for 9％and GⅡ accounting for 90％.Additionally,49 polymerase types(P-type)were identified,along with 68 combinations of CP types;among the analyzed recombinant sequences(4 460 entries in total),approxi-mately 41％belonged to three predominant recombinant strains:GⅡ.2[P16],GⅡ.4[P31],and GⅡ.4[P16].This analysis provides valuable insights into the distribution characteristics of norovirus genotypes across Asia and Russia over time,thereby supporting vac-cine design and evaluation efforts.关键词
诺如病毒/胃肠炎/基因型Key words
norovirus/gastroenteritis/genetic diversity分类
基础医学引用本文复制引用
姜慧敏,陈燕,李利利,孙晓曼,薛垂召,李金松,裴银辉,段招军..基于GenBank分析1995-2023年间亚洲地区及俄罗斯诺如病毒基因型别分布和变迁[J].中国人兽共患病学报,2025,41(5):515-521,7.基金项目
北京市自然科学基金(No.L232011) Beijing Natural Science Foundation(No.L232011) （No.L232011）
