中国输血杂志2025，Vol.38Issue(6)：777-781,5.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.005
血液制剂输注对创伤性脑损伤患者预后的影响
Impact of blood component transfusion on the prognosis of patients with traumatic brain injury
摘要
Abstract
Objective To investigate the effects of blood component transfusion on the prognosis of patients with varying severity of traumatic brain injury(TBI).Methods A retrospective analysis was conducted on clinical data from 621 TBI patients admitted between January 2012 and December 2022.The patients in the blood transfusion group were categorized into three groups based on Glasgow Coma Scale(GCS)scores:severe impairment(GCS 3-8,n=302),moderate impair-ment(GCS 9-12,n=186),and mild impairment(GCS 13-14,n=133).General clinical data and laboratory test inde-xes were analyzed.Patients were further divided into two subgroups based on in-hospital mortality:death group(n=72)vs survival group(n=549).Univariate and multivariate logistic regression analysis was used to analyze the effects of different blood component transfusion volumes on the prognosis of TBI patients.ROC curve was used to evaluate the prognostic value of red blood cell transfusion volume.Results Patients with GCS scores 3-8 had significantly longer hospital stays(21.73±15.89 vs 20.83±11.54 vs 15.5±7.76)and higher RBC transfusion volumes(6.16±6.79 vs 4.67±2.81 vs 3.67±3.20)than the other two groups(P<0.05).NLR,PCT,CRP,PT,Fib,FDP and DDI after the last transfusion showed signifi-cant differences from pre-transfusion values(P<0.05).The death group exhibited higher transfusion volumes of RBCs,plas-ma,platelets,and cryoprecipitate compared with the survival group(P<0.05).Univariate(OR:1.541,95%CI:1.412-1.682)and multivariate(OR:1.522,95%CI:1.362-1.700)logistic regression analyses showed that the RBC transfusion volume was a risk factor affecting the prognostic factors of TBI patients after infusion of blood components.ROC curve analy-sis showed that RBC transfusion volume could serve as a prognostic marker(sensitivity:0.708,specificity:0.812).Con-clusion Blood component transfusion alters inflammatory and coagulation markers in patients with different degrees of TBI,and RBC transfusion volume is a viable prognostic indicator for TBI outcomes.关键词
创伤性脑损伤/炎症/凝血功能/血液制剂输注Key words
traumatic brain injury/inflammation/coagulation/transfusion of blood component分类
医药卫生引用本文复制引用
姚祺敏,陈诚,王志成,夏荣..血液制剂输注对创伤性脑损伤患者预后的影响[J].中国输血杂志,2025,38(6):777-781,5.基金项目
国家自然科学基金面上项目(82370232) （82370232）
