中国实用妇科与产科杂志2025，Vol.41Issue(6)：649-652,4.DOI:10.19538/j.fk2025060115
hCG日血清黄体生成素水平对体外受精-胚胎移植后活产率的预测价值
Predictive value of serum LH level on hCG administration day on live birth rate after in vitro fertilization-embryo transfer treatment
摘要
Abstract
Objective To assess the value of the serum luteinizing hormone(LH)level on the human chorionic gonadotropin(hCG)administration day for predicting the live birth rate(LBR)after in vitro fertilization-embryo transfer(IVF-ET)treatment.Methods This was a retrospective cohort study.A total of 378 female patients were included,who underwent IVF-ET treatment with the gonadotropin-releasing hormone(GnRH)antagonist protocol and had their first fresh cycle embryo transfer at Tianjin Medical University General Hospital from June 2017 to April 2024.All patients received ovulation induction treatment with the GnRH antagonist protocol and were divided into a low-LH group(LH ≤1.67U/L)and a high-LH group(LH＞1.67U/L)according to the serum LH level on the hCG administration day.Evaluate the effects of such factors as the LH level on the hCG administration day,body mass index(BMI),and ovarian reserve function on the pregnancy outcome.Results There were no significant differences in the biochemical pregnancy rate,clinical pregnancy rate,or live birth rate between the low-LH group and high-LH group(P＞0.05).However,the regression analysis showed that female age,the number of transferred embryos,and the thickness of the endometrium were significantly correlated with the live birth rate(P＜0.05).The predictive role of the LH level on the hCG administration day in the pregnancy outcome did not show independence,while age and endometrial thickness might be stronger predictors for the live birth rate.Conclusions The LH level on the hCG administration day,as an independent predictor,does not play a significant role in the prediction of the live birth rate after treatment,indicating that it might not be a decisive factor affecting the pregnancy outcome.Nevertheless,such factors as age and endometrial thickness play an important role in predicting the live birth rate,suggesting that the success rate of IVF-ET treatment should be evaluated individually by combining multiple physiological indicators.关键词
人绒毛膜促性腺激素/黄体生成素/体外受精/活产率/促性腺激素释放激素拮抗剂Key words
hCG/LH/in vitro fertilization/live birth rate/GnRH antagonist分类
医药卫生引用本文复制引用
许艳萍,田烨,宋学茹..hCG日血清黄体生成素水平对体外受精-胚胎移植后活产率的预测价值[J].中国实用妇科与产科杂志,2025,41(6):649-652,4.基金项目
天津市医学重点学科(专科)建设项目(TJYXZDXK-031A) （专科）
国家自然科学基金面上项目(82171625) Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-031A) （82171625）
General Program of the National Natural Science Foundation of China(82171625) （82171625）
