中国输血杂志2025，Vol.38Issue(6)：797-802,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.008
PEscore对血液病患者血小板输注疗效预测的应用效果评价
Evaluation of PEscore performance in predicting platelet transfusion efficacy in hematological patients
摘要
Abstract
Objective To evaluate the performance of platelet efficacy score(PEscore)in predicting platelet transfu-sion efficacy in hematological patients.Methods A total of 485 patients with hematological diseases,including 298 males(62.09±15.45 years)and 187 females(59.17±16.52 years)who received platelet transfusion from January 1,2021 to December 31,2024 were enrolled in this study.Clinical data of the patients such as diagnosis,gender,age,number of platelet transfusion,and platelet antibody data were analyzed to investigate the incidence and influencing factors of platelet transfusion refractoriness in hematological patients at our hospital.ROC curve was used to evaluate the performance of PEscore model in predicting platelet transfusion efficacy.The predictive performance of PEscore model was validated by cal-culating its sensitivity,specificity,and accuracy in 115 clinical cases.Results The incidence of platelet transfusion re-fractoriness in 485 cases was 29.90%(145/485).Significant differences(P<0.05)were observed between the effective and ineffective platelet transfusion groups regarding the following factors:diagnosis:lymphoma[55.32%(26/47)vs 44.68%(21/47)],the number of previous platelet transfusions[≥25:60.78%(31/51)vs 39.22%(20/51)],platelet antibody screening result[positive:33.76%(53/157)vs 66.24%(104/157)],and platelet transfusion volume(×1011/L)[>6:62.71%(74/118)vs 37.29%(44/118)].The area under the ROC curve of PEscore was 0.876.The cut-off points and corresponding sensitivity and specificity were 19.90.59%and 69.44%,respectively.The results of clinical application showed that the sensitivity,specificity and accuracy of the PEscore model for predicting platelet transfusion were 87.50%,93.41%and 92.17%,respectively.Conclusion The incidence of platelet transfusion refractoriness in hematological pa-tients is relatively high.PEscore prediction model has a good performance in predicting the effect of platelet transfusion,which can provide a reliable basis for predicting the effect of platelet transfusion in hematological patients before blood trans-fusion.关键词
PEscore/血小板输注疗效/应用效果Key words
PEscore/platelet transfusion efficacy/performance分类
医药卫生引用本文复制引用
李君,王澜,谢怡华,陈子奇,赵刚..PEscore对血液病患者血小板输注疗效预测的应用效果评价[J].中国输血杂志,2025,38(6):797-802,6.基金项目
河北省医学科学研究课题计划资助(20231864) （20231864）
