中国输血杂志2025，Vol.38Issue(6)：803-810,8.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.009
红细胞Kidd血型分布及基因型特异性与冠心病患病风险相关性研究
Association of Kidd blood group distribution and genotypes specificity with the risk of coronary heart disease
摘要
Abstract
Objective To investigate the distribution characteristics of Kidd blood group antigens,phenotypes and gen-otypes in Xinjiang and their influence on the risk of coronary heart disease.Methods Samples from 7 981 patients treated at People's Hospital of Xinjiang Uygur Autonomous Region from August 1,2023 to May 31,2024 were collected for Jk(a-b-)phenotype screening via urea hemolysis test,followed by the third-generation sequencing(TGS).Kidd blood group Jka and Jkb antigens in 1 081 patients with coronary heart disease and 1 021 healthy people were detected,and their phenotype frequency distribution was analyzed and corresponding gene frequencies were calculated.Correlation analysis and logistic re-gression were used to evaluate the influence of Kidd blood group antigen expression on coronary heart disease risk.Results Two Jk(a-b-)phenotype samples were detected,both resulting from novel gene mutation combinations.Comparative a-nalysis of two groups revealed a higher proportion of the Jk(a-b+)phenotype in the case group(22.5%,243/1 081)than in the control group(18.5%,189/1 021).Moreover,Kidd blood group phenotype distribution varied significantly across all ethnic groups in the case group(P<0.05).In the control group,the Hui ethnic group exhibited the highest JKa JKb genotype frequency 64.15%(34/53).In the case group,the highest JKa allele frequency was observed in Mongol ethnic group 56.31%(125/222),and the lowest in Han patients 45.71%(341/746).The expression of Jka antigen was nega-tively correlated with coronary heart disease(P<0.05).Conclusion The distribution of Kidd blood group system varied across ethnic groups in Xinjiang.The expression of Jka antigen may have protective effect on coronary heart disease,which provides a basis for future clinical blood transfusion treatment and the mechanism study of the correlation between Kidd blood group and coronary heart disease.关键词
Kidd血型/Jk(a-b-)表型/抗原/冠心病/基因/新疆Key words
Kidd blood type/Jk(a-b-)phenotype/antigens/coronary heart disease/gene/Xinjiang分类
医药卫生引用本文复制引用
李菲,邱进,李慧君,马筱洁,赵铁锁,陈伟..红细胞Kidd血型分布及基因型特异性与冠心病患病风险相关性研究[J].中国输血杂志,2025,38(6):803-810,8.基金项目
新疆维吾尔自治区自然科学基金项目(2022D01C637) （2022D01C637）
新疆维吾尔自治区"天山英才"医药卫生高层次人才项目(TSYC202401B157) （TSYC202401B157）
