中国输血杂志2025，Vol.38Issue(6)：811-816,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.010
南宁地区壮族献血人群IgA含量分布特征及对输血安全影响初探
Distribution characteristics of IgA in Zhuang blood donors and its influence on blood transfusion safety in Nanning
摘要
Abstract
Objective To analyze the distribution characteristics of immunoglobulin A(IgA)concentration in Nanning Zhuang blood donors by measuring the concentration of plasma IgA.Methods Enzyme-linked immunosorbent assay(ELISA)was performed to measure the absorbance of 2 000 plasma samples from Zhuang blood donors.The IgA concentra-tion in samples was calculated using the ELISA Calc regression/fitting technology program.Results The standard curve demonstrated that ELISA detection of plasma IgA concentration exhibited good precision.The frequency of IgA deficiency was 0/2 000.No statistically significant difference in the distribution of IgA concentration was observed between males and females(P>0.05).The distribution of IgA concentration varied significantly across age groups:younger individuals(18-39 years old)had lower plasma IgA levels(mg/dL)compared to older individuals(40-56 years old):5-89.99 mg/dL group,8.80%(176/2 000)vs 17.20%(344/2 000);90-450 mg/dL group,20.65%(413/2 000)vs 51.20%(1 024/2 000);>450 mg/dL group,0.45%,(9/2 000)vs 1.70%(34/2 000),P<0.05.No significant difference in IgA con-centration was found among different ABO blood types in Zhuang blood donors(P>0.05).Spearman correlation analysis re-vealed a positive correlation between age and IgA concentration(RS=0.114,P<0.05).Conclusion No individuals with IgA deficiency were screened out among the Zhuang blood donors in Nanning area,and plasma IgA levels progressively in-crease with age.关键词
壮族人群/IgA缺乏症/发生率/输血安全Key words
Zhuang blood donors/IgA deficiency/frequency/transfusion safety分类
医药卫生引用本文复制引用
莫秋红,陈洋,赖铭霜,莫慧慧,何保仁,黄宝甲,唐艳娅,黄林宾,陈利民..南宁地区壮族献血人群IgA含量分布特征及对输血安全影响初探[J].中国输血杂志,2025,38(6):811-816,6.基金项目
广西卫健委自筹经费科研课题(Z20201430) （Z20201430）
