中国输血杂志2025，Vol.38Issue(6)：817-823,7.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.011
GLMM框架下广州成分献血者铁代谢动态变化及健康宣教效果研究
Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guang-zhou under the GLMM framework
摘要
Abstract
Objective To investigate the current status of iron metabolism among apheresis donors in Guangzhou and analyze the improvement effects of health education on iron deficiency in frequent apheresis donors.Methods Using a gen-eralized linear mixed model(GLMM),a 180-day follow-up was conducted on 261 eligible apheresis donors at the Guang-zhou Blood Center from January to July 2024.Hemoglobin(Hb),serum ferritin(SF),unsaturated iron-binding capacity(UIBC),total iron-binding capacity(TIBC),and transferrin saturation(TS)were selected as outcome variables.The effects of gender,age group,and number of donations within 180 days on these outcomes were analyzed and modeled.A general linear model(GLM)with repeated measures was applied to 55 donors who received health education interventions,comparing changes in Hb and iron metabolism-related indicators before and after follow-up and health education.Results No significant difference in Hb levels was observed between first-time and regular apheresis donors,but SF levels were sig-nificantly higher in first-time donors(F=6.195,P<0.05).The GLMM revealed that female donors exhibited more signifi-cant reductions in Hb(T=-12.546)and SF(T=-5.829)(P<0.05 for both).Age group showed no interactive effects on Hb or SF changes.While number of donations within 180 days had no interactive effect on Hb,SF levels significantly de-creased with increased number of donations(using≥9 donations as the reference group;P<0.05 for all groups).After health education,Hb levels remained unchanged,but SF increased compared to pre-intervention levels(mean difference:-18.571,P<0.05),though a declining trend persisted compared to baseline(mean difference from baseline to post-inter-vention:23.068,P<0.05).Conclusion Female and number of donations are primary factors contributing to SF reduction in apheresis donors.Health education interventions promote SF recovery.Extending donation intervals and reinforcing iron deficiency-related health education may improve iron status in donors.关键词
成分献血/铁代谢/健康宣教/广义线性混合效应模型/非贫血性铁缺乏Key words
apheresis platelets donation/iron metabolism/health education/generalized linear mixed model/non-a-naemic iron deficiency分类
医药卫生引用本文复制引用
陈晓文,李繁海,钟笔,刘光欢,陈锦艳,王淏,黎世杰..GLMM框架下广州成分献血者铁代谢动态变化及健康宣教效果研究[J].中国输血杂志,2025,38(6):817-823,7.基金项目
广州市科学技术局科技计划项目(2023A03J0697) （2023A03J0697）
