中国中医药信息杂志2025，Vol.32Issue(7)：127-133,7.DOI:10.19879/j.cnki.1005-5304.202501484
强身口服液指纹图谱研究及质量标志物预测
Study on the Fingerprint and Prediction of Quality Markers of Qiangshen Oral Liquid
摘要
Abstract
Objective To establish a fingerprint spectrum for Qiangshen Oral Liquid;To predict its quality markers combined with network pharmacology.Methods HPLC-ELSD method was used to establish fingerprint spectrum of Qiangshen Oral Liquid,and common peaks were identified.Its targets and related pathways were predicted through network pharmacology.A component-target-pathway network was constructed,and molecular docking verification was performed to analyze the quality markers of Qiangshen Oral Liquid.Results The HPLC fingerprint spectrum of Qiangshen Oral Liquid was established.20 common peaks were identified and belonged to all prescription drug tastes.13 chromatographic peaks were located using reference standards.The similarity evaluation showed that the similarity of 19 batches of Qiangshen Oral Liquid ranged from 0 to 0.995.Network pharmacology identified 45 key targets related to 13 components,and KEGG enrichment analysis obtained 151 pathways.A component-target-pathway network was constructed,predicted that calycosin-7-O-glucoside,ginsenoside Rg1,ginsenoside Re,ginsenoside Rf,ginsenoside Rb1,astragaloside Ⅳ,ginsenoside Rd,ginsenoside Rb2,astragaloside Ⅱ,astragaloside Ⅰ,schisandrin A and panaxatriol were quality markers for Qiangshen Oral Liquid.Conclusion The fingerprint spectrum of Qiangshen Oral Liquid was established,and quality markers were predicted preliminarily,providing a reference for its standard establishment and quality evaluation.关键词
强身口服液/指纹图谱/质量标志物/网络药理学/分子对接Key words
Qiangshen Oral Liquid/fingerprint spectrum/quality marker/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
杨鑫,刘艳梅,张妍,肖小武,洪挺..强身口服液指纹图谱研究及质量标志物预测[J].中国中医药信息杂志,2025,32(7):127-133,7.基金项目
国家药品监督管理局药品监管科学体系建设重点项目(RS2024Z006) （RS2024Z006）
江西省药品监督管理局科技项目(2023JS01) （2023JS01）
