中国医学装备2025，Vol.22Issue(6)：7-13,7.DOI:10.3969/j.issn.1672-8270.2025.06.002
基于射波刀的肝癌立体定向放射治疗计划中两种优化算法的效果评估
Performance assessment of CyberKnife-based SBRT plans with VoLO and SO algorithm for liver cancer
摘要
Abstract
Objective:To assess performance advantages of voxel-less optimization(VoLO)algorithm of CyberKnife-based S7 treatment plan system for the optimization of stereotactic body radiation therapy(SBRT)for liver cancer.Methods:The case data of 20 patients with hepatocellular carcinoma from Chinese PLA General Hospital during June 2022 and April 2023 were retrospectively selected,which included 10 patients with large hepatocellular carcinoma and 10 patients with small hepatocellular carcinoma.All patients adopted respectively sequential optimization(SO)and VoLO to conduct optimization for plan.The optimized quality of plan and execution efficiency of two kinds of algorithms were assessed,and the influences of different tumor volumes also were considered.The planed quality assessment included dosimetric parameters of the target region and organ at risk(OAR).The assessment parameters of execution efficiency included the numbers of monitor units(MUs),nodes and beams,and estimated treatment time.Paired t-test method was adopted to analyze quality of plan and treatment efficiency.Results:On the aspect of the dose of target region,for small hepatocellular carcinoma,the conformity index(CI)value(1.08±0.05)of target region of VoLO algorithm was significantly better than(1.17±0.06)of SO algorithm(t=4.631,P<0.05).The gradient index(GI),coverage rate and dose by 95%(D95%)of VoLO algorithm were better than those of SO algorithm,while the differences were not significant(P>0.05).According to the defined standards of liver surgery,for large hepatocellular carcinoma,the differences in CI,GI,coverage rate and D95%of target region between two kinds of algorithms were significant(t=3.337,4.238,-3.359,-3.311,P<0.05),respectively.On the aspect of dosimetry for OAR,for the target region of large hepatocellular carcinoma,the differences of liver Dmean and D700 cm3 between two kinds of algorithms were significant(t=4.114,3.415,P<0.05).However,for small hepatocellular carcinoma,there was no significant statistical difference in dosimetry parameters of OAR between two kinds of algorithms(P>0.05).The execution efficiency of the plan of VoLO group was obviously higher than that of SO group,and the differences of MU number,node number,beam number and estimated treatment time between two groups were significant(t=12.661,4.423,5.024,9.487,P<0.05).Conclusion:The quality of VoLO plan is significantly better than that of SO,which has a significant improvement in execution efficiency of treatment.For the cases of large hepatocellular carcinoma with more complexity,the VoLO optimization shows better advantages on the aspect of dose on target region,and protection for normal liver.关键词
射波刀/顺序优化(SO)算法/体素减少优化(VoLO)算法/肝癌/立体定向放射治疗Key words
CyberKnife/Optimal algorithm/Voxel-less optimization(VoLO)algorithm/Liver cancer/Stereotactic body radiationtherapy(SBRT)分类
临床医学引用本文复制引用
吴韶鹃,鞠忠建,李玉,巩汉顺,曲宝林,刘小亮,谷珊珊,戴相昆..基于射波刀的肝癌立体定向放射治疗计划中两种优化算法的效果评估[J].中国医学装备,2025,22(6):7-13,7.基金项目
国家重点研发计划(2022YFC2409501、2023YFC2411504) National Key Research and Development Program of China(2022YFC2409501,2023YFC2411500) （2022YFC2409501、2023YFC2411504）
