中国医学装备2025，Vol.22Issue(6)：81-85,5.DOI:10.3969/j.issn.1672-8270.2025.06.016
自身抗体检测对不同类型桥本甲状腺炎诊断价值研究
Study on the diagnostic value of detecting autoantibodies for Hashimoto's thyroiditis
孟庆晗 1雷蕾 1赵晋文 1刘千赫 1刘紫旺 1王苗苗 1马海娜 1王欣俞1
作者信息
摘要
Abstract
Objective:To explore the diagnostic value of the combined detection of v-Kirsten Ras viral oncogene homolog(KRAS),transmembrane protein 243(TMEM243),cell division cycle protein 42(CDC42)and RAS like family 11 member B(RASL11B)for different types of Hashimoto's thyroiditis(HT).Methods:From January 2023 to December 2024,a total of 185 HT patients who received detection in Hebei Yanda Hospital were selected by using a random number table method,and they were divided into three groups according to HT type,which included the euthyroid HT group(65 cases),the hypothyroid HT group(60 cases)and the hyperthyroidism HT group(60 cases).Another 65 healthy individuals who underwent physical examination during the same period were selected as the healthy control group.An analyzer of enzyme-linked immunosorbent assay(ELISA)was used to measure and analyze the levels of KRAS,TMEM243,CDC42 and RASL11B in the four groups.Differences in autoantibody levels among different HT patients were compared.Logistic regression analysis was conducted to assess influence factors for HT.A nomogram model was constructed to realize visual presentation on the basis of the influence factors.Receiver operating characteristic(ROC)curves were adopted to assess the diagnostic efficacy of antibodies for subjects in the four groups.Results:The KRAS,TMEM243,CDC42 and RASL11B levels in the three HT groups were significantly higher than those in the healthy control group(F=906.962,840.078,830.290,846.182,P<0.05),respectively.Multivariate logistic regression analysis showed that KRAS,TMEM243,CDC42 and RASL11B were risk factors for HT(OR=4.071,1.424,1.026,1.031,P<0.05).The area under curve(AUC)of the ROC curve of the combined detection of four indicators of autoantibodies was 0.975,which sensitivity and specificity were respectively 94.05%and 92.31%.Conclusion:There were overexpression of KRAS,TMEM243,CDC42 and RASL11B in HT patients,especially,the overexpression of hyperthyroidism HT patients is more significant.The combined detection of the four indicators of autoantibody has favorable performance and clinical reference value in diagnosing HT.关键词
酶标分析/桥本甲状腺炎/自身抗体/诊断效能Key words
Enzyme linked immunosorbent assay(ELISA)/Hashimoto's thyroiditis(HT)/Autoantibody/Diagnostic efficacy分类
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孟庆晗,雷蕾,赵晋文,刘千赫,刘紫旺,王苗苗,马海娜,王欣俞..自身抗体检测对不同类型桥本甲状腺炎诊断价值研究[J].中国医学装备,2025,22(6):81-85,5.
