中国医学装备2025，Vol.22Issue(6)：163-169,7.DOI:10.3969/j.issn.1672-8270.2025.06.031
质谱技术在临床检验中的研究及应用进展
Progress of research and application of MS technology in clinical laboratory
摘要
Abstract
Mass spectrometry(MS)is one of the core technology in the field of clinical laboratory,which has a series of advantages include high sensitivity,high specificity,and the simultaneous analysis of multi-components.It shows great potential in metabolite detection,proteomic analysis,etc.,which can provide new pathways for early diagnosis and personalized treatment of complex diseases.In recent years,the research of MS technique appears rapid development trend in the field of clinical laboratory.This paper systematically combed the application status and research progress of MS techniques in clinical laboratory,which include mass spectrometry imaging(MSI),matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),inductively coupled plasma mass spectrometry(ICP-MS),cytometry by time-of-flight(CyTOF),and liquid chromatography-tandem mass spectrometry(LC-MS/MS).It focused on their practical applications in disease diagnosis,efficacy assessment,and prognosis judgment,and it anatomized the faced bottlenecks and problems of current technique.Based on the frontline technological trends,it explore the innovative directions of integrating MS technique with emerging bioinformatics,microfluidics,etc.,so as to provide theoretical basis and practical reference for promoting the standardized and intelligent development of MS technique in clinical laboratory,and help its wide application in clinical diagnosis and treatment.关键词
临床检验/质谱成像(MSI)技术/基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)技术/电感耦合等离子体质谱(ICP-MS)技术/飞行时间质谱流式细胞(CyTOF)技术/液相色谱-串联质谱(LC-MS/MS)技术分类
临床医学引用本文复制引用
刘桂红,黎蔚波,林惠霞,冯双喜,张建华..质谱技术在临床检验中的研究及应用进展[J].中国医学装备,2025,22(6):163-169,7.基金项目
广州市卫生健康科技一般引导项目(20221A011110) The General Guiding Project of Guangzhou Health Technology(20221A011110) （20221A011110）
