中国输血杂志2025，Vol.38Issue(6)：843-848,6.DOI:10.13303/j.cjbt.issn.1004-549x.2025.06.016
Rh系统抗-c引起胎儿新生儿溶血病1例并文献复习
Hemolytic disease of the fetus and newborn caused by Rh system anti-c antibodies:a case report and literature re-view
摘要
Abstract
Objective To summarize the laboratory findings of a case of hemolytic disease of the fetus and newborn(HDFN)caused by Rh system anti-c antibodies and to review the literature,so as to explore the characteristics of anti-c HDFN.Methods The ABO blood type,Rh blood type,direct antiglobulin test(DAT)results,and the presence of unex-pected antibodies and their titers were determined by serological methods.The cases of anti-c HDFN in our laboratory in Chi-na and abroad were statistically analyzed,and the incidence of severe HDFN caused by anti-c,anti-D and anti-E was com-pared.Results The blood type of the child was B(Rh CcDee)with a positive DAT.Anti-c antibody was detected in both serum and eluate,with a serum antibody titer of 4.The mother's blood type was AB(Rh CCDee)with a negative DAT,and anti-c antibody was detected in the serum with a titer of 128.Among 20 cases of anti-c HDFN,17 were DAT positive,and 9(45%,9/20)underwent blood transfusion or exchange transfusion.The incidence of severe HDFN was 47.60%(10/21)for anti-c,47.60%(10/21)for anti-D and 31.30%(5/16)for anti-E.Conclusion Maternal pregnancy and/or blood transfusion are the main reasons for the production of Rh alloantibodies such as anti-c.The prevention and manage-ment of anti-c should be similar to that of anti-D.Rh antigen-matched(five antigens of Rh blood group)transfusion is nec-essary for women of childbearing age to avoid antibody production,and Rh typing and antibody screening during prenatal ex-amination is recommended to ensure early detection,intervention and treatment.关键词
Rh血型系统/抗-c/直接抗人球蛋白试验/胎儿新生儿溶血病Key words
Rh blood group system/anti-c antibody/direct antiglobulin test(DAT)/hemolytic disease of the fetus and newborn(HDFN)分类
医药卫生引用本文复制引用
陈鲁燕,向东,吕定丰,刘振云,朱心怡,陶栓,应琪明,梁伟..Rh系统抗-c引起胎儿新生儿溶血病1例并文献复习[J].中国输血杂志,2025,38(6):843-848,6.基金项目
中国人口福利基金会医学创新课题(SLB-6-20230912-351) （SLB-6-20230912-351）
宁波市科技局2022年度重点研发计划暨"揭榜挂帅"项目(2022Z2202022) （2022Z2202022）
宁波市科技局重点项目(2023J020) （2023J020）
浙江省医药卫生科技项目(2024KY1495) （2024KY1495）
