中国实验动物学报2025，Vol.33Issue(5)：656-664,9.DOI:10.3969/j.issn.1005-4847.2025.05.004
乳腺癌荷瘤裸鼠模型证候属性和姜制江香薷多糖的影响
Impact of ginger-processed Jiangxiangru polysaccharides on establishment of a breast cancer tumor-bearing nude mice model and its pathological characteristics
摘要
Abstract
Objective To observe the characteristic symptoms in breast cancer-bearing mice and the beneficial effect of ginger-processed Jiangxiangru polysaccharides on traditional Chinese medical symptoms.Methods Thirty-eight mice were used for modeling and divided into normal,model,positive,and low-,medium-,and high-dose ginger-processed Jiangxiangru polysaccharide groups.Mice in the normal group were not inoculated with tumors and mice in the normal and model groups received physiological saline intragastrically.Mice in the positive group received celecoxib solution intragastrically,and mice in the low-,medium-,and high-dose groups received the same dose but different concentrations of ginger-processed Jiangxiangru polysaccharide solution intragastrically.Changes in body weight and tumor size were recorded after 4 weeks of continuous administration.Symptoms were observed at the end of the experiment.RGB values in photographs of the tongues,tails,and claws from mice in each group were analyzed and recorded.The degrees of blood deficiency,yin deficiency,and tumor phlegm stasis were calculated based on the method of quantitative dialectical diagnosis.The tumors were isolated and weighed,and the tumor volume and inhibition rate were calculated to determine the beneficial effect of ginger-processed Jiangxiangru polysaccharides on traditional Chinese medical symptoms.Results Mice in the breast cancer model group showed signs of blood deficiency,yin deficiency,and phlegm stasis.Tumor size was significantly reduced in mice in the ginger-processed Jiangxiangru polysaccharide groups.Ginger-processed Jiangxiangru polysaccharides inhibited tumor growth and improved blood deficiency,yin deficiency,and tumor phlegm stasis in breast cancer-bearing mice,with the best result in the high-dose group.Conclusions Ginger-processed Jiangxiangru polysaccharides can improve the symptoms of blood deficiency,yin deficiency,and tumor phlegm stasis in breast cancer-bearing mice,especially at high doses.关键词
姜制江香薷多糖/乳腺癌/病症结合模型/中医证候Key words
ginger-processed Jiangxiangru/breast cancer/disease combination model/TCM symptoms分类
生物科学引用本文复制引用
黄帅,马秋婷,洪滔,钟祥铭,张文凯,黄云,刘志勇..乳腺癌荷瘤裸鼠模型证候属性和姜制江香薷多糖的影响[J].中国实验动物学报,2025,33(5):656-664,9.基金项目
江西省教育厅科技项目(GJJ180661),江西中医药大学校级科技创新团队发展计划(CXTD-22004).Funded by Science and Technology Project of Jiangxi Provincial Department of Education(GJJ180661),School-Level Science and Technology Innovation Team Development Programme of Jiangxi University of Chinese Medicine(CXTD-22004). （GJJ180661）
