中国实验动物学报2025，Vol.33Issue(5)：704-720,17.DOI:10.3969/j.issn.1005-4847.2025.05.009
特发性肺纤维化动物模型及中药干预作用的研究进展
Research progress in animal models of idiopathic pulmonary fibrosis and interventional effect of traditional Chinese medicine
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a chronic progressive disease with a short survival time after diagnosis.Current treatments using western medicines have shown poor efficacy and lung transplantation is costly,highlighting the need to find new,safe,and effective treatments.Animal experiments are important for investigating the mechanisms of drug action,and suitable animal models of IPF are required for experimental research.Bleomycin is commonly used to induce IPF models.Traditional Chinese medicine(TCM)has the advantages of multiple therapeutic targets and few adverse reactions,and is gradually gaining attention for the treatment of IPF.Ongoing experimental research is being carried out to verify the specific targets and mechanisms of TCM in the treatment of IPF,utilizing animal models of IPF.This review considers the selection of animal models of IPF,the method used to induce,establish,and evaluate the models,and the interventional effects of TCM.We also summarize the best modeling method for animal models of IPF and the current status of TCM treatments to provide a basis for further scientific research and the clinical treatment of IPF.关键词
特发性肺纤维化/中药干预作用/动物模型/造模方法/造模过程/模型评价Key words
idiopathic pulmonary fibrosis/intervention of traditional Chinese medicine/animal model/modeling method/modeling process/model evaluation分类
生物学引用本文复制引用
张震,邹吉宇,臧凝子,王天娇,庞立健,吕晓东..特发性肺纤维化动物模型及中药干预作用的研究进展[J].中国实验动物学报,2025,33(5):704-720,17.基金项目
国家自然科学基金面上项目(82274440),辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-040).Funded by General Project of National Natural Science Foundation of China(82274440),Liaoning Provincial Department of Education University Basic Scientific Research Project Reserve Project(2024-JYTCB-040). （82274440）
