中国实验动物学报2025，Vol.33Issue(5)：730-738,9.DOI:10.3969/j.issn.1005-4847.2025.05.011
Ercc1基因缺陷模型在衰老相关疾病中的研究进展
Research advances on Ercc1-deficient models in aging-related diseases
摘要
Abstract
DNA repair is essential for the successful replication of genetic material and for transcriptional fidelity.Excision repair cross-complementation group 1(Ercc1)is a structure-specific nucleic acid endonuclease that repairs DNA damage by participating in the nucleotide excision repair and DNA double-strand break repair pathways.The accumulation of various types of molecular and cellular damage over time lead to aging.Defects in Ercc1 are associated with malfunctions in DNA damage repair,resultsing in the accumulation of cellular damage and ultimately inducing aging.This paper summarizes the biological functions of Ercc1 during DNA damage and the phenotypes of Ercc1-deficient mouse models,and discusses the biological effects of Ercc1 in different tissues associated with senescence and age-related degenerative diseases.This review highlights potential intervention targets and provides a theoretical basis for the development of innovative therapeutics,animal models,and drug discovery for senescence-associated diseases.关键词
切除修复交叉互补组1/DNA损伤/DNA修复/Ercc1缺陷小鼠模型/衰老相关疾病Key words
excision repair cross-complementation group 1/DNA damage/DNA repair/Ercc1-deficient mouse model/aging-related diseases分类
生物科学引用本文复制引用
徐源,杨永生,张天,张岩..Ercc1基因缺陷模型在衰老相关疾病中的研究进展[J].中国实验动物学报,2025,33(5):730-738,9.基金项目
科技部重点研发计划中医药现代化重点专项(2023YFC3504305).Funded by Key Special Project for Modernization of Traditional Chinese Medicine of the Ministry of Science and Technology(2023YFC3504305). （2023YFC3504305）
