中国实验动物学报2025，Vol.33Issue(5)：739-755,17.DOI:10.3969/j.issn.1005-4847.2025.05.012
慢性疼痛伴焦虑动物模型的建立及针刺干预效应的研究进展
Overview of construction of effector platforms and behavioral assessments of acupuncture intervention in animal models of chronic pain accompanied by pain anxiety
摘要
Abstract
Chronic pain has emerged as a prevalent medical challenge in contemporary society.Patients suffering from chronic pain frequently develop comorbid psychological disorders,including anxiety,depression,post-traumatic stress disorder,and various psychiatric syndromes.These psychological complications not only affect patients' pain perception and responses,but may also constitute critical obstacles during pain management interventions.Acupuncture is a long-established clinical practice that has demonstrated remarkable efficacy in alleviating diverse pain types and has shown favorable therapeutic outcomes in ameliorating emotional disturbances such as anxiety and depression.The precise mechanisms underlying acupuncture-induced analgesia and anxiolytic effects,however,remain to be fully elucidated.In this context,it is essential to establish suitable and stable animal models to allow in-depth investigations into the pathogenesis of pain-related emotional disorders and the mechanistic foundations of acupuncture.This article presents a comprehensive review of recent literature regarding the selection of experimental animals,model-establishment method ologies,and behavioral-assessment paradigms pertaining to animal model platforms of chronic pain with comorbid anxiety.We also provide an in-depth discussion of research advancements regarding acupuncture intervention parameters,including needling techniques,acupoint selection,treatment duration,and efficacy evaluation within these animal models.This review proposes comprehensive and reference strategies for constructing preclinical animal models to investigate the mechanisms of acupuncture in managing chronic pain with comorbid anxiety,thus supporting scientific advancements in related research fields.关键词
针刺/慢性痛/焦虑/动物模型/行为学评估Key words
acupuncture/chronic pain/anxiety/animal model/behavioral assessment分类
生物科学引用本文复制引用
司雨欣,张庆祥,安家莹,张祐霖,张淼,傅予,于玉杰,张涵,房钰鑫..慢性疼痛伴焦虑动物模型的建立及针刺干预效应的研究进展[J].中国实验动物学报,2025,33(5):739-755,17.基金项目
天津市教委科研计划项目(2023ZD027).Funded by the Science & Technology Development Fund of Tianjin Education Commission for Higher Education(2023ZD027). （2023ZD027）
