中国实验动物学报2025，Vol.33Issue(5)：756-769,14.DOI:10.3969/j.issn.1005-4847.2025.05.013
特发性肺纤维化动物模型的研究进展
Research progress in animal models of idiopathic pulmonary fibrosis
摘要
Abstract
As a chronic progressive lung disease with poor prognosis,the pathogenesis of idiopathic pulmonary fibrosis(IPF)has not yet been clarified,and its treatment is still being explored.Animal models are important tools for studying the pathogenesis and therapeutic effects of diseases.Based on the similarity between animal models and human of IPF in terms of disease phenotype,this paper will review the research progress of IPF animal models in terms of the fibrosis mechanism induced by drugs and environmental factors,histopathological alterations,fibrosis stage,modelling time,etc.,and describe the advantages and disadvantages of different animal models,their characteristics and application profiles.关键词
特发性肺纤维化/动物模型/表型Key words
idiopathic pulmonary fibrosis/animal models/phenotype分类
生物科学引用本文复制引用
檀丽丽,黄巍,杨子璇,阙平鑫毅,张宏,唐宋琪..特发性肺纤维化动物模型的研究进展[J].中国实验动物学报,2025,33(5):756-769,14.基金项目
国家自然科学基金(82474436),成都中医药大学附属医院基金(2017-D-YY-15).Funded by National Natural Science Foundation of China(82474436),Hospital Fund of Chengdu University of Traditional Chinese Medicine(2017-D-YY-15). （82474436）
