中国实验动物学报2025，Vol.33Issue(5)：770-778,9.DOI:10.3969/j.issn.1005-4847.2025.05.014
苯酚胶浆在妇科疾病动物模型中的应用
Application of phenolic adhesive slurry in animal models of gynecological diseases
摘要
Abstract
The phenol glue modeling method is a widely used modeling technique in animal experimental models of gynecological diseases.Phenol glue is injected into the rat uterus as an adhesive agent,causing chemical burns to the pelvic organ tissues,to construct animal models of pelvic inflammatory disease,cervicitis,endometritis,salpingitis,vaginitis,and other gynecological diseases.The burns induce hyperemia,edema,inflammatory exudation,inflammatory adhesions,and blockages,leading to chronic inflammation.The corrosive and adhesive properties of phenol paste are also used to create animal models replicating gynecological diseases in traditional Chinese medicine,based on the syndrome of dampness and blood stasis.The successful establishment of the phenol glue model provides a crucial experimental basis for studying the pathological mechanisms and treatment method of gynecological diseases.关键词
苯酚胶浆/妇科疾病/动物模型/中医证型Key words
phenolic paste/gynecological diseases/animal models/TCM syndrome and signs分类
生物科学引用本文复制引用
王广龙,张锁..苯酚胶浆在妇科疾病动物模型中的应用[J].中国实验动物学报,2025,33(5):770-778,9.基金项目
内蒙古自治区蒙医药协同创新中心科研项目(MYYXTPY202301),内蒙古教育厅青年英才科技计划项目(NJYT22022),内蒙古自治区卫健委项目(202201224),名中医朱宗元教授验方配伍规律及作用机制研究创新团队(20220922),内蒙古自治区科技厅(2020LH08017).Funded by Inner Mongolia Autonomous Region Mongolian Medicine Collaborative Innovation Center Scientific Research Project(MYYXTPY202301),Inner Mongolia Education Department Young Elite Science and Technology Plan Project(NJYT22022),Inner Mongolia Autonomous Region Health Commission Project(202201224),Research Innovation Team on the Compatibility Rules and Mechanism of Action of the Proven Prescriptions of Professor Zhu Zongyuan,a Famous Traditional Chinese Medicine Doctor(20220922),Inner Mongolia Autonomous Region Science and Technology Department(2020LH08017). （MYYXTPY202301）
