组织工程与重建外科杂志2025，Vol.21Issue(3)：250-257,266,9.DOI:10.3969/j.issn.1673-0364.2025.03.006
中国先天性巨大黑痣的流行病学以及危险因素调查研究
The survey research of epidemiology and risk factors of large to giant congenital melanocytic nevi in China
摘要
Abstract
Objective To explore the relationship between clinical phenotype and clinical manifestations of large-to-giant congenital melanocytic nevi(LGCMN),analyze the differences in risk factors during the embryonic period between normal children and patients with congenital melanocytic nevi(CMN),and provide a new strategy for the prevention of this disease.Methods In total,125 patients diagnosed with congenital melanocytic nevi(CMN)were recruited and completed the questionnaire,which contained questions about phenotype,clinical manifestations,family history,and risk factors during pregnancy.In the control group,66 parents of children without CMN were asked questions about their family history and pregnancy risk factors.Results Pruritis or ulceration was correlated with projected adult size(P=0.007),satellite nevi(OR=4.712,P=0.035),and complications(OR=13.377,P=0.006).Lesion rugosity was significantly associated with lesion bulge(OR=22.873,P<0.001).Malignant melanoma developed in 1.6%of the CMN patients;both had LGCMN and>20 satellites.CMN incidence was significantly associated with a family history of hyperpigmentation disorders(26.4%vs.6.06%,P<0.001),complications during pregnancy(48.0%vs.28.8%,P=0.019)and a history of chemical substance exposure(15.2%vs.1.5%,P=0.007).Conclusion This study provides novel clues about the association between phenotypes and manifestations and provides potential knowledge on the LGCMN aetiology.In addition,analysis of family history and risk factors during pregnancy also provides strategies for prevention of the disease.关键词
先天性黑痣/流行病学/危险因素/表型Key words
Congenital melanocytic nevi/Epidemiology/Risk factor/Phenotype分类
临床医学引用本文复制引用
赖柏翰,魏伯轩,金佳敏,顾婕妤,谢峰..中国先天性巨大黑痣的流行病学以及危险因素调查研究[J].组织工程与重建外科杂志,2025,21(3):250-257,266,9.基金项目
上海市科学技术委员会临床医学研究中心项目(22MC1940300). （22MC1940300）
