中国中医药信息杂志2025，Vol.32Issue(7)：14-18,5.DOI:10.19879/j.cnki.1005-5304.202405325
基于正邪理论探讨自噬在糖尿病心肌病中的作用及中药干预
Exploration on the Role of Autophagy in Diabetic Cardiomyopathy Based on the Theory of Healthy Qi and Pathogenic Factors and Chinese Materia Medica Intervention
摘要
Abstract
The struggle between healthy qi and pathogenic factors runs through the whole process of the formation and development of diabetic cardiomyopathy(DCM),and autophagy is the main regulator of cardiac homeostasis and function.Based on the theory of healthy qi and pathogenic factors,the autophagy state of DCM was understood.In the early stage of DCM,it is mainly characterized by deficiency of healthy qi and supplemented by pathogenic excess.In the middle stage,it is characterized by deficiency of healthy qi and pathogenic excess.In the late stage,it is mainly characterized by pathogenic excess and supplemented by deficiency of healthy qi.TCM clinical practice adheres to the principle of"strengthening the healthy qi and eliminating pathogenic factors",which aims to restore the dynamic balance of autophagy in the body by adjusting the balance between healthy qi and pathogenic factors,and ultimately improve the prognosis of DCM.This article took the theory of healthy qi and pathogenic factors as the starting point,and elaborated on the role of autophagy in the development of DCM from macro and micro perspectives.It explored Chinese materia medica intervention plans for different stages of DCM,providing theoretical reference for the regulation of autophagy in DCM by TCM.关键词
糖尿病心肌病/自噬/正邪理论/中药Key words
diabetic cardiomyopathy/autophagy/theory of healthy qi and pathogenic factors/Chinese materia medica分类
医药卫生引用本文复制引用
张垚,杨梦,俞赟丰,胡志希..基于正邪理论探讨自噬在糖尿病心肌病中的作用及中药干预[J].中国中医药信息杂志,2025,32(7):14-18,5.基金项目
国家自然科学基金(82274412) （82274412）
湖南省自然科学基金(2020JJ4062、2020JJ5408) （2020JJ4062、2020JJ5408）
