组织工程与重建外科杂志2025，Vol.21Issue(3)：267-270,4.DOI:10.3969/j.issn.1673-0364.2025.03.008
脉冲染料激光治疗新生儿红斑与葡萄酒色斑的疗效对比
Comparative efficacy of pulsed dye laser in the treatment of salmon patch and port-wine stain and exploration of strategies
摘要
Abstract
Objective To compare the efficacy of pulsed dye laser(PDL)in treating salmon patch(SP)and port-wine stain(PWS)in V1 area.Methods A retrospective case-control study was conducted on 40 untreated patients(22 with SP,18 with PWS in the V1 area),who underwent 3 sessions of PDL treatment(spot size:7 mm;fluence:8-11 J/cm2;pulse duration:0.45-1.5 ms).Improvement in lesion color and size(graded 0-5)before and after treatment was evaluated using standardized photographs and visual analog scale(VAS)scores,while adverse effects were recorded.Differences in efficacy were analyzed using the t-test.Results The mean VAS scores were significantly higher in SP patients than in PWS patients(color improvement:3.68±1.13 vs.1.44±1.38;size improvement:3.36±1.26 vs.1.22±1.17;P<0.01).Significant improvement was achieved in SP after≤3 treatments,and PWS was less effective after 3 treatments.Regarding safety,only one case of SP exhibited transient hyperpigmentation.Histological analysis revealed that the mean depth of SP vessels was(212.90±35.70)μm,significantly shallower than that of PWS(＞400 μm),suggesting that PDL is more effective for superficial vessels.Conclusion PDL was significantly more effective for SP than for PWS,likely due to differences in vessel depth.关键词
毛细血管畸形/葡萄酒色斑/新生儿红斑/脉冲染料激光/光动力治疗Key words
Capillary malformation/Port-wine stain/Salmon patch/Pulsed dye laser/Photodynamic therapy分类
临床医学引用本文复制引用
张立忻,马刚,林晓曦..脉冲染料激光治疗新生儿红斑与葡萄酒色斑的疗效对比[J].组织工程与重建外科杂志,2025,21(3):267-270,4.基金项目
上海市临床重点专科整形外科项目(shslc-zdzk00901) （shslc-zdzk00901）
上海交通大学医工(理)交叉基金资助(YG2019QNB10) （理）
上海市卫生健康委员会卫生行业临床研究专项(202240150),上海交通大学医学院附属第九人民医院横向课题(JYHX2021007,JYHX2021008). （202240150）
