中国中医药信息杂志2025，Vol.32Issue(7)：55-61,7.DOI:10.19879/j.cnki.1005-5304.202406437
基于真实世界研究数据挖掘王仲易治疗儿童抽动障碍用药规律
Study on the Medication Law of Wang Zhongyi in Treating Tic Disorder Based on Data Mining
摘要
Abstract
Objective To study the medication law of Professor Wang Zhongyi in the treatment of tic disorder(TD)based on data mining technology.Methods From January 1,2022 to December 31,2023,the cases treated for TD in Professor Wang Zhongyi's outpatient clinic,which participated in the real-world study were collected.A comprehensive database has been established,screening information related to effective case diagnosis and treatment.Utilizing Excel 2021,R 4.4.2,Origin 2024 and Cytoscape 3.9.1,this study conducted medication frequency analysis,property-flavor-meridian tropism analysis,efficacy analysis,association rule analysis,clustering analysis and co-occurrence network analysis to summarize medication law.Results Totally 640 effective prescriptions were included,involving 208 kinds of Chinese materia medica.The properties were mainly warm,cold,and neutral.The flavors were mainly pungent,bitter and sweet.The meridians were mainly liver meridians.The therapeutic categories were primarily composed of liver-calming and endogenous wind-stopping drugs,along with exterior-resolving prescriptions.Correlation analysis obtained 17 strongly correlated rules.Clustering analysis obtained 5 types of medicinal combinations.The therapeutic categories were primarily composed of liver-calming and endogenous wind-stopping drugs,along with exterior-resolving prescriptions.Conclusion According to the comprehensive statistical analysis,Uncariae Ramulus cum Uncis,Gastrodiae Rhizoma,Haliotidos Concha,Paeoniae Radix alba,Bupleuri Radix,Puerariae Lobatue Radix and Scorpio are the core drugs used by Professor Wang Zhongyi to treat TD.Professor Wang Zhongyi believes that the core pathogenesis of TD is the internal movement of liver wind,and the treatment mainly focuses on calming the liver,calming the wind and stopping spasms,while also nourishing the heart,calming the mind,harmonizing blood and relieving qi.Based on different clinical symptoms of TD,modifications and adjustments are made to the core prescription to treat children with TD.关键词
抽动障碍/用药规律/数据挖掘/中医Key words
tic disorder/medication law/data mining/TCM分类
医药卫生引用本文复制引用
范洪伟,李敏,邱小金,吕小琴,常莹,王仲易..基于真实世界研究数据挖掘王仲易治疗儿童抽动障碍用药规律[J].中国中医药信息杂志,2025,32(7):55-61,7.基金项目
国家中医药管理局中医药循证能力建设项目(2019XZZX-EK001) （2019XZZX-EK001）
