中国药理学通报2025，Vol.41Issue(7)：1201-1205,5.DOI:10.12360/CPB202412014
小胶质细胞调节突触可塑性在抑郁症中的研究进展
Research progress of microglia regulation of synaptic plasticity in depression
摘要
Abstract
Depression,characterized by high incidence,high re-lapse rate and high suicide rate,is an affective disorder mainly characterized by low mood and often accompanied by suicidal tendency,which seriously endangers human health.In recent years,more and more evidence suggests that microglia regulate synaptic plasticity and play an important role in depression.Here we outline the recent research progress of microglia regula-ting synaptic plasticity to exert antidepressant effects,focusing on three main types of molecular signals regulating synaptic pruning in microglia,including"Find Me"signaling,"Eat Me"signaling and"Don't Eat Me"signaling.By reviewing recent studies on how microglia regulate synaptic plasticity in depression,hopeful-ly,the understanding of microglia-mediated synaptic plasticity can be strengthened,which can help to provide new strategies for the treatment of depression by targeting microglia or microglia-associated signaling pathways.关键词
抑郁症/小胶质细胞/突触可塑性/突触修剪/突触吞噬/突触丢失Key words
depression/microglia/synaptic plasticity/synaptic pruning/synaptic engulfment/synapse loss分类
基础医学引用本文复制引用
赖华清,范平龙,王真真,陈乃宏..小胶质细胞调节突触可塑性在抑郁症中的研究进展[J].中国药理学通报,2025,41(7):1201-1205,5.基金项目
国家自然科学基金资助项目(No 82130109) （No 82130109）
