中国药理学通报2025，Vol.41Issue(7)：1206-1211,6.DOI:10.12360/CPB202410032
丝切蛋白调控前列腺癌进展的作用机制及潜在的治疗策略
Mechanism of cofilin in regulating prostate cancer progression and potential therapeutic strategies
摘要
Abstract
The molecular mechanisms underlying the develop-ment and metastasis of prostate cancer remain elusive.This comprehensive review delves into the intricate role of cofilin,an actin-binding protein,in the pathogenesis and progression of prostate cancer.Cofilin is a significant protein in cytoskeletal dynamics,and any dysregulation may result in the morphological changes in normal cells and the invasion and metastasis of tumor cells.Research has revealed that the activity of cofilin is regula-ted by various mechanisms,including phosphorylation/dephos-phorylation and interactions with other molecules.Moreover,this review discusses promising therapeutic interventions,such as co-filin inhibitors and gene therapy,which have demonstrated effica-cy in preclinical models.The challenge of clinically preventing the transition to castration-resistant prostate cancer and tumor metastasis is widely recognized,necessitating the development of precise drug treatments and biomarker identification.As a key regulatory protein,cofilin provides a more comprehensive refer-ence for the prevention and treatment of prostate diseases.关键词
丝切蛋白/切割/肌动蛋白结合蛋白/细胞骨架/前列腺癌/磷酸化Key words
cofilin/cleavage/actin-binding protein/cytoskele-ton/prostate cancer/phosphorylation分类
基础医学引用本文复制引用
符方智,吴丽通,冯恩敏,赵祥,王能,王彪,周青..丝切蛋白调控前列腺癌进展的作用机制及潜在的治疗策略[J].中国药理学通报,2025,41(7):1206-1211,6.基金项目
国家自然科学基金区域创新发展联合基金重点支持项目(No U20A20408) （No U20A20408）
国家自然科学基金面上项目(No 82374460) （No 82374460）
湖南省一类中医重点专科中医男科(湘中医药函(2023)4号) （湘中医药函(2023）
