中国药理学通报2025，Vol.41Issue(7)：1211-1216,6.DOI:10.12360/CPB202409086
Galectin-3作为炎症信号在溃疡性结肠炎中的研究进展
Progress of galectin-3 as an inflammatory signal in ulcerative colitis
摘要
Abstract
Ulcerative colitis(UC)is a chronic inflammatory dis-ease of the colon and rectum with an unclear etiology.Early di-agnosis and effective treatment of UC are still urgent challenges that need to be addressed in clinical practice.More and more studies have found that galectin-3 is involved in the occurrence and development of UC,which may become a biomarker for the diagnosis and treatment of UC.Galectin-3,widely expressed in colonic epithelial cells and immune cells,can regulate intestinal immunity and play an important role in the occurrence and de-velopment of inflammation.This article provides a brief intro-duction to the structure and function of galectin-3,and summari-zes and discusses the expression changes and roles of galectin-3 in UC.At present,most literature reports believe that galectin-3 plays a pro-inflammatory role in UC,but there are still some re-ports that hold the opposite view.This article analyzes the rea-sons for this controversy and provides a reference for further de-termining whether galectin-3 may become a diagnostic indicator and therapeutic target for UC.关键词
galectin-3/结肠/溃疡性结肠炎/炎症/炎症性肠病/诊断标志物/治疗靶点Key words
galectin-3/colon/ulcerative colitis/inflammation/inflammatory bowel disease/diagnostic biomarker/therapeutic target分类
医药卫生引用本文复制引用
郑子明,潘祥林..Galectin-3作为炎症信号在溃疡性结肠炎中的研究进展[J].中国药理学通报,2025,41(7):1211-1216,6.基金项目
国家自然科学基金项目(No 82104282) （No 82104282）
武汉市中心医院院级科研项目(No 22YJ01) （No 22YJ01）
中国药学会医院药学专业委员会人才专项资助项目(No CPA-Z05-ZC-2023-003) （No CPA-Z05-ZC-2023-003）
武当特色中药研究湖北省重点实验室开放课题(No WDCM2024013) （No WDCM2024013）
