中国药理学通报2025，Vol.41Issue(7)：1222-1226,5.DOI:10.12360/CPB202406089
工程化MSCs-EV修复软骨损伤聚焦:递送姜黄素
Engineered MSCs-EV for repairing cartilage damage with a focus on delivery of curcumin
摘要
Abstract
Mesenchymal stem cells(MSCs)play a crucial role in tissue repair and regeneration,and the extracellular vesicle(EV)released by them holds great promise for applications in clinical biomarkers,vaccines,and drug delivery.However,MSCs-derived EV(MSCs-EV)face challenges such as low pro-duction yield,poor retention,and targeted delivery issues.There-fore,engineering MSCs-EV to enhance their performance and en-able visual research has become a hot topic.Curcumin(CUR),an active component in traditional chinese medicine,exhibits pharmacological effects but has limited bioavailability.Using MSCs-EV as a carrier for CUR delivery can address its solubility and bioavailability challenges.This article reviews the drug loading methods,engineering strategies of MSCs-EV,and their important applications in the delivery and treatment of CUR for cartilage injury diseases.It provides a basis for the clinical ap-plication of engineered MSCs-EV in CUR delivery for cartilage repair,offering potential solutions to the challenges in cartilage tissue repair.关键词
姜黄素/间充质干细胞/细胞外囊泡/软骨/工程化/骨关节炎Key words
curcumin/mesenchymal stem cells/extracellular vesicles/cartilage/tissue engineering/osteoarthritis分类
中医学引用本文复制引用
杜晓明,马钰林,段学庆,杨照熙,张宪哲,章津铭,胡一梅..工程化MSCs-EV修复软骨损伤聚焦:递送姜黄素[J].中国药理学通报,2025,41(7):1222-1226,5.基金项目
国家自然科学基金资助项目(No 82174262) （No 82174262）
成都中医药大学附属医院科研能力"百人计划"(No 22-Y14) （No 22-Y14）
