中国药理学通报2025，Vol.41Issue(7)：1227-1230,4.DOI:10.12360/CPB202411024
酒精摄入对非酒精性脂肪肝发病进程的影响及潜在机制研究进展
Effects of alcoholism on nonalcoholic fatty liver disease
摘要
Abstract
NAFLD is the most prevalent chronic liver disease,which has become a world public health issue and the incidence rate is also showing an increasing trend.A series of liver disea-ses,such as simple fatty liver disease,NASH,liver cirrhosis,liv-er failure and liver cancer,can be collectively referred to as NAFLD.Through the study of numerous factors that influence the production of NAFLD,it has been found that the main patho-logical mechanism is excessive synthesis of fat,which is difficult to be transported into the blood,causing massive lipid accumula-tion.Alcohol has a direct damaging effect on liver and will in-hibit the breakdown of liver fat,eventually forming AFLD.How-ever,it is still controversial whether alcohol has a synergistic effect on NAFLD onset.This article provides a review on the effect of alcohol intake on NAFLD and its potential mechanisms of action.关键词
非酒精性脂肪肝/酒精/酒精摄入对脂肪肝的两面性/肝损伤/发病机制/研究进展Key words
nonalcoholic fatty liver disease/alcohol/dual effects of alcohol intake on fatty liver/liver damage/pathogene-sis/research progress分类
医药卫生引用本文复制引用
朱昊清,吴艳玲,南极星,廉丽花..酒精摄入对非酒精性脂肪肝发病进程的影响及潜在机制研究进展[J].中国药理学通报,2025,41(7):1227-1230,4.基金项目
国家自然科学基金资助项目(No 82460803,82074095,82360850) （No 82460803,82074095,82360850）
