中国药理学通报2025，Vol.41Issue(7)：1231-1236,6.DOI:10.12360/CPB2022410052
Nogo-A/NgR通路对经典致幻剂降低小鼠前脉冲抑制反应的影响
Effect of Nogo-A/NgR pathway on prepulse inhibition reduction induced by psychedelics in mice
摘要
Abstract
Aim To explore the effect of neurite out-growth inhibitor A/neurite outgrowth inhibitor receptor(Nogo-A/NgR)pathway on psychedelic-reduced pre-pulse inhibition in mice.Methods Mice were injec-ted intraperitoneally with psilocybin,DOI to establish an animal model of prepulse inhibition(PPI)reduc-tion.The effects of psilocybin and DOI on PPI in mice after lateral ventricular injection of Nogo-A inhibitor NEP1-40 30 min in advance were evaluated.Finally,Rtn4r knockout mice were constructed to further verify the conclusion.Results The injection of NEP1-40(1 g·L-1,5 μL/mice,i.c.v)30 min in advance had no effect on PPI of mice.Under the conditions of 70 dB and 75 dB prepulse stimulation,NEP1-40 significantly up-regulated the PPI reduction induced by psilocybin.At the same time,NEP1-40 significantly up-regulated the DOI induced PPI reduction in mice at 70 dB and 80 dB prepulse stimulation.Compared with the two solvent groups,the PPI of Rtn4r-/-mice was not differ-ent from that of wild-type mice.Compared with the mice in Rtn4r-/-solvent group,the PPI of mice in Rtn4r-/-administration group showed a decreasing trend,but had no significant difference.Under the con-dition of 70 dB prepulse stimulation,there was a signif-icant difference between the Rtn4r-/-administration group and wild-type mice.Conclusion Nogo-A/NgR pathway is involved in the destruction of sensorimotor gating in mice by the psychedelic psilocybin or DOI.关键词
经典致幻剂/动物模型/前脉冲抑制/Nogo-A蛋白/NgR受体/Rtn4r基因敲除Key words
psychedelic/animal model/prepulse inhi-bition/Nogo-A protein/NgR receptor/Rtn4r gene knockout分类
医药卫生引用本文复制引用
曲颖,王悦颖,孙毅,苏瑞斌..Nogo-A/NgR通路对经典致幻剂降低小鼠前脉冲抑制反应的影响[J].中国药理学通报,2025,41(7):1231-1236,6.基金项目
军事医学研究院国家安全特需药品全国重点实验室自主科学研究项目(No LTMC2022ZZ003) （No LTMC2022ZZ003）
