中医临床研究2025，Vol.17Issue(8)：36-43,8.DOI:10.3969/j.issn.1674-7860.2025.08.006
中药复方防治结直肠腺瘤的用药规律与作用机制分析
An analysis of medication patterns and mechanisms of traditional Chinese medicine compound prescriptions in preventing and treating colorectal adenoma
摘要
Abstract
Objective:This study aims to investigate the medication patterns and mechanisms of traditional Chinese medicine(TCM)compound prescriptions in preventing and treating colorectal adenomas(CRA).Methods:Literature on TCM compound prescriptions for CRA was retrieved from Chinese databases,and a prescription database was constructed for frequency analysis.Association rule analysis of Chinese medicines was conducted using SPSS Modeler,and clustering analysis was performed using IBM SPSS Statistics 27.Drug-disease targets were obtained from TCMSP platform and GeneCards,and a PPI network model was constructed using STRING database and Cytoscape 3.10.1 to identify key targets.GO and KEGG enrichment analyses of intersecting targets were performed using DAVID database.A"drug-active ingredient-target-disease"network was built using Cytoscape 3.10.1 to identify core active ingredients.Finally,the binding ability of key active ingredients and core gene targets was verified by molecular docking.Results:A total of 39 papers were included according to the inclusion exclusion criteria,obtaining 42 valid prescriptions involving 135 Chinese medicines.The predominant tastes of these Chinese medicines were sweet and bitter,with mostly warm and neutral properties.The most frequently used Chinese medicines included Baizhu(Rhizoma Atractylodis Macrocephalae),Gancao(Radix Glycyrrhizae),and Dangshen(Radix Codonopsis)."Baizhu-Dangshen-Gancao"was the core Chinese medicines group with 120 active ingredients and 120 intersecting targets with CRA.The key active ingredients against CRA were quercetin and kaempferol,and the core targets were tumor protein p53(TP53),signal transducer and activator of transcription 3(STAT3)and interleukin 6(IL-6),etc.GO analysis indicated involved biological processes such as positive regulation of gene expression,while the key pathways analyzed by KEGG were pathway in cancer and so on.Molecular docking revealed strong binding affinities of key active ingredients quercetin and kaempferol with core targets TP53,STAT3 and IL-6,with quercetin showing the strongest binding affinity with TP53.Conclusion:The Chinese medicine compound prescriptions against CRA is based on strengthening the spleen and vital energy,resolving turbidities and detoxifying toxins,and the core group of drugs,"Baizhu-Dangshen-Gancao",may play a role in the prevention and treatment of CRA by modulating the targets such as TP53,STAT3,and IL-6 to influence the biological processes such as gene expression and cell apoptosis.关键词
结直肠腺瘤/槲皮素/山柰酚/肿瘤蛋白p53/癌症通路Key words
Colorectal adenoma/Quercetin/Kaempferol/TP53/Pathways in cancer分类
医药卫生引用本文复制引用
赵凤露,肖君..中药复方防治结直肠腺瘤的用药规律与作用机制分析[J].中医临床研究,2025,17(8):36-43,8.基金项目
南京中医药大学自然科学基金(XZR2023039). （XZR2023039）
