Abstract
Objective:To summarize the prescription regularity of traditional Chinese medicine(TCM)in the treatment of emphysema based on data mining technology.Methods:Literature about TCM prescription for treatment of emphysema from the databases of CNKI,VIP,Wanfang database,and SinoMed were searched from the building to March 31,2024.The TCMISS V2.5 was used to analyze the used frequency,four properties and five flavors,meridial distribution,commonly used herb-pairs and herb combinations.The revised mutual information,and complex system entropy clustering methods were used to analyze the herb association rules and core herb combinations.The unsupervised entropy hierarchical clustering method was used for new prescription analysis.Results:A total of 262 prescriptions were screened,involving 225 kinds of herb.There were 43 kinds of herb with frequency more than 20,including Fuling(Poria),Gancao(Glycyrrhizae Radix et Rhizoma),Wuweizi(Schisandrae Chinensis Fructus),Xingren(Armeniacae Semen Amarum),Huangqi(Astragali Radix),Fabanxia(Pinelliae Rhizoma Praeparatum),etc.The four properties were mainly warm and cold,and the five flavors were mainly sweet,bitter and pungency,and the active ingredients were mainly attributed to the lung meridian,the spleen meridian,the heart meridian,and the kidney meridian.There were 56 herb combinations with frequency≥20,including Fuling-Wuweizi,Chenpi(Pericarpium Citri Reticulatae)-Fuling,Baizhu(Rhizoma Atractylodis macrocephalae)-Fuling,Gancao-Fuling,Gancao-Xingren,Fabanxia-Gancao,Fabanxia-Xingren,etc.A total of 18 prescription regularities,33 herb combinations with association coefficients≥0.03,24 core combinations,and 12 potential new prescriptions were obtained.Conclusion:In the treatment of emphysema,TCM practitioners mostly use herbs to replenish deficiency[including Qi(气)replenishment,blood replenishment and Yin(阴)replenishment],resolve phlegm,stop cough and asthma,and clear away heat.The TCM practitioners shows that the main treatment is to replenish the spleen,lungs,kidneys and heart(especially to replenish the Qi),to resolve phlegm,to stop cough and asthma,to clear away and remove the heat from the lung,and to remove the fire and toxins,which reflects the idea of treating the lungs,kidneys,spleen,and heart together to treat both the symptoms and root causes of the disease.关键词
肺气肿/组方规律/数据挖掘Key words
Emphysema/Prescription regularity/Data minings分类
医药卫生
