中国药理学通报2025，Vol.41Issue(7)：1340-1345,6.DOI:10.12360/CPB202412024
红景天苷对帕金森小鼠炎性反应的影响
Salidroside alleviates progression of Parkinson's disease by modulating inflammatory responses
摘要
Abstract
Aim To explore the neuroprotective effects of salidroside on Parkinson's disease(PD)through modulation of inflammatory responses and the underly-ing mechanisms.Methods Mice were divided into five groups:healthy control group,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)disease group,low-dose Rhodioloside intervention group,medium-dose salidroside intervention group,and high-dose salidro-side intervention group.MPTP-induced PD mouse model was established,and salidroside intervention was administered.Behavioral changes,inflammatory cyto-kine levels,autophagy-related protein expression,and neurons were observed through histological analysis and immunohistochemical staining.Results After MPTP treatment,mice exhibited significant behavioral chan-ges,increased pro-inflammatory cytokines,decreased anti-inflammatory cytokines,reduced autophagy-related proteins,and evident pyroptosis.Salidroside interven-tion alleviated these changes in a dose-dependent man-ner.Conclusions Salidroside exerts neuroprotective effects on PD by alleviating inflammatory responses and promoting autophagy,thereby protecting neurons.关键词
红景天苷/帕金森病/运动障碍/炎性反应/自噬/细胞焦亡Key words
salidroside/Parkinson's disease/move-ment disorder/inflammatory response/autophagy/py-roptosis引用本文复制引用
董小林,邬刚,李妍平,张丽娟,金富蓉,李锐,李红梅,张晓晓,李青芸..红景天苷对帕金森小鼠炎性反应的影响[J].中国药理学通报,2025,41(7):1340-1345,6.基金项目
云南省科技厅基础研究项目(No 202401AY070001-333) （No 202401AY070001-333）
云南省教育厅课题(No 2024J0284) （No 2024J0284）
云南省心血管疾病重点实验室开发课题(No 2022SPR-01) （No 2022SPR-01）
