中国药理学通报2025，Vol.41Issue(7)：1376-1381,6.DOI:10.12360/CPB202410070
大蒜超细粉改善小鼠动脉粥样硬化及血脂异常的作用机制
Mechanism of ultrafine garlic powder in improving mouse atherosclerosis and dyslipidemia
摘要
Abstract
Aim To investigate the mechanism of ultra-fine garlic powder(UGP)in ameliorating dyslipidemia and aortic inflammation and fibrosis in atherosclerotic(AS)mice.Methods A 10-week ApoE-/-mouse AS model was constructed,cardiac index was meas-ured,and aortic histopathological changes were ob-served by oil red O staining.Serum inflammatory factor levels were detected by ELISA,and the expression of JNK,NF-κB,ERK and their phosphorylated proteins were detected by Western blot.Results Cardiac in-dex and other indicators as well as aortic lesions were worsened in the AS group,as compared with the normal control group.Compared with the AS group,the UGP treatment group and the traditional garlic grinding pow-der(TGP)treatment group significantly decreased total cholesterol(TC),triglyceride(TG),low-density lipo-protein cholesterol(LDL-C),atherosclerosis index(AI1,AI2),and coronary cardiac index and restored high-density lipoprotein cholesterol(HDL-C)levels,and the area of aortic lesions,inflammation and fibrosis were significantly improved,and at the same time,sig-nificantly inhibited the expression of TNF-α,IL-1β,and IL-6,as well as the expression of p-JNK,p-NF-κB and p-ERK proteins.The therapeutic effect of the UGP group was superior to that of the TGP group.Conclu-sion UGP can significantly inhibit the formation of aortic endothelial AS plaques,reduce the levels of in-flammation and fibrosis,and regulate blood lipids in a-orta of AS mice.关键词
大蒜超细粉/动脉粥样硬化/血脂异常/炎症/纤维化/MAPK信号通路Key words
ultrafine garlic powder/atherosclerosis/dyslipidemia/inflammation/fibrosis/MAPK signaling pathway分类
医药卫生引用本文复制引用
邵宁宁,杨剑明,王耀光,张涛,赵效铭,董津睿..大蒜超细粉改善小鼠动脉粥样硬化及血脂异常的作用机制[J].中国药理学通报,2025,41(7):1376-1381,6.基金项目
国家自然科学基金资助项目(No 82200655) （No 82200655）
天津市自然科学基金资助项目(No 22JCYBJC0073,023JCYBJC01560) （No 22JCYBJC0073,023JCYBJC01560）
