浙江大学学报（农业与生命科学版）2025，Vol.51Issue(3)：366-378,13.DOI:10.3785/j.issn.1008-9209.2023.12.083
杆状病毒蛋白入核转运的分子机制研究进展
Research progress on molecular mechanisms of nuclear-imported transport for baculovirus proteins
摘要
Abstract
Baculovirus is a type of virus with a double-stranded,circular,and superhelical DNA structure.The replication and transcription of viral genes,as well as the assembly of progeny virions,occur in the nucleus of the cell.However,owing to the natural barrier of the cell nuclear membrane,macromolecular substances larger than 40-60 kDa cannot directly penetrate the nuclear membrane.Therefore,viruses have evolved different strategies to achieve transmembrane transport of viral proteins.The classical nuclear transport pathways that rely on nuclear localization signal(NLS)and non-classical nuclear transport pathways that do not rely on NLS derived from baculovirus were summarized in this review.Moreover,during the nuclear transport process,viruses regulate the nuclear pathway through protein modifications,host structure changes,and other strategies,thereby creating a favorable environment for the nuclear transport of viral proteins.关键词
杆状病毒/核定位信号/核转运受体/核孔复合体/蛋白质修饰Key words
baculovirus/nuclear localization signal/nuclear transport receptor/nuclear pore complex/protein modification分类
农业科技引用本文复制引用
李佳乐,王星洋,吴小锋..杆状病毒蛋白入核转运的分子机制研究进展[J].浙江大学学报（农业与生命科学版）,2025,51(3):366-378,13.基金项目
国家自然科学基金项目(32172793) （32172793）
国家重点研发计划项目"政府间国际科技创新合作专项"(2022YFE0124400). （2022YFE0124400）
