中国中西医结合杂志2025，Vol.45Issue(6)：672-677,6.DOI:10.7661/j.cjim.20241213.162
加味通窍活血汤对基底节脑出血立体定向穿刺术后患者脑水肿及预后影响
Effect of Modified Tongqiao Huoxue Decoction on Cerebral Oedema and Patients Prognosis after Stereotactic Puncture for Cerebral Haemorrhage of the Basal Ganglia
摘要
Abstract
Objective To study the effect of modified Tongqiao Huoxue Decoction on cerebral oedema and patient prognosis after stereotactic puncture for cerebral haemorrhage in the basal ganglia.Methods Forty-seven patients with basal ganglia hemorrhage who underwent stereotactic hematoma puncture and aspiration at the Xiaoshan Hospital in Zhejiang from November 2019 to November 2023 were enrolled in this study.Patients were assigned to a treatment group(25 cases)and a control group(22 cases)according to the order of admission.Both groups received treatments to control intracranial pressure,maintain blood pressure stability,prevent postoperative complications,and nutritional support.The treatment group began taking the modified Tongqiao Huoxue Decoction starting on the 7th day postoperatively.The results of head CT and the scores of each neurological function assessment scale were observed at 1 day,7 days,30 days,and 6 months postoperatively.The Barthel Index Scale for Activities of Daily Living(ADL),National Institutes of Health Stroke Scale(NIHSS),Glasgow Outcome Scale Expanded(GOSE),Modified Rankin Scale(MRS),and volume of cerebral oedema were used as the indexes for evaluating the neurological function,and the therapeutic efficacy of modified Tongqiao Huoxue Decoction was assessed.Results On the 30th postoperative day,compared with the control group,patients in the treatment group showed a decrease in MRS scores(P＜0.05)and an increase in GOSE and ADL scores(P＜0.05).At the 6-month postoperative mark,there was no statistically significant difference in MRS and GOSE scores between the treatment and control groups(P＞0.05).Similarly,at the 30th postoperative day and the 6-month mark,there was no statistically significant difference in cerebral edema volumes between the treatment and control groups(P＞0.05).The incidence of complications during hospitalization in both groups also showed no statistically significant difference(P＞0.05).Conclusions Patients with basal ganglia hemorrhage experienced accelerated neurologic recovery within 30 days after stereotactic puncture and drainage of the hematoma,through the administration of the modified Tongqiao Huoxue Decoction.However,its impact on neurologic recovery at six months post-surgery was not significant.关键词
基底节脑出血/立体定向穿刺术/加味通窍活血汤/神经功能/脑水肿/预后/中药复方/中西医结合Key words
basal ganglia hemorrhage/stereotactic puncture/modified Tongqiao Huoxue Decoction/nerve function/cerebral edema/prognosis/Chinese herbal compound/integrative medicine引用本文复制引用
来铁枫,王科,沈张锋,窦千,金圣榆,胡兵,许冬冬,陈宇浩..加味通窍活血汤对基底节脑出血立体定向穿刺术后患者脑水肿及预后影响[J].中国中西医结合杂志,2025,45(6):672-677,6.基金项目
浙江省中医药科技计划项目(No.2020ZB211) （No.2020ZB211）
