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Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Genhui Xiao Yumeng Cui Liangliang Zhou Chuya Niu Bing Wang Jinglan Wang Shaoyang Zhou Miaomiao Pan Chi Kin Chan Yan Xia Lan Xu Yu Lu Shawn Chen

mLife2025，Vol.4Issue(2)：P.155-168,14.

mLife2025，Vol.4Issue(2)：P.155-168,14.DOI:10.1002/mlf2.12169

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria

Genhui Xiao ¹Yumeng Cui ¹Liangliang Zhou ¹Chuya Niu ¹Bing Wang ²Jinglan Wang ¹Shaoyang Zhou ¹Miaomiao Pan ¹Chi Kin Chan ¹Yan Xia ¹Lan Xu ¹Yu Lu ²Shawn Chen¹

作者信息

1. Global Health Drug Discovery Institute,Beijing,China
2. Beijing Key Laboratory of Drug Resistance Tuberculosis Research,Beijing Tuberculosis and Thoracic Tumor Research Institute,and Beijing Chest Hospital,Capital Medical University,Beijing,China
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摘要

关键词

caseinolytic protease/chemical-genetic interaction/drug combination/enzyme inhibitor/mycobacteria

分类

医药卫生

引用本文复制引用

Genhui Xiao,Yumeng Cui,Liangliang Zhou,Chuya Niu,Bing Wang,Jinglan Wang,Shaoyang Zhou,Miaomiao Pan,Chi Kin Chan,Yan Xia,Lan Xu,Yu Lu,Shawn Chen..Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria[J].mLife,2025,4(2):P.155-168,14.

基金项目

supported by the Bill&Melinda Gates Foundation(grant number:INV-008249) （grant number:INV-008249）

GHDDI sponsors in Beijing,China. （）

mLife

ISSN：2097-1699

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