首页|期刊导航|Neural Regeneration Research|Low-density lipoprotein receptor–related protein 1 mediatesα-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease

Low-density lipoprotein receptor–related protein 1 mediatesα-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease

Hanjiang Luo Caixia Peng Chengli Wu Chengwei Liu Qinghua Li Shun Yu Jia Liu Min Chen

Neural Regeneration Research2026，Vol.21Issue(4)：P.1595-1606,12.

Neural Regeneration Research2026，Vol.21Issue(4)：P.1595-1606,12.DOI:10.4103/NRR.NRR-D-23-01965

Low-density lipoprotein receptor–related protein 1 mediatesα-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease

Hanjiang Luo ¹Caixia Peng ²Chengli Wu ²Chengwei Liu ²Qinghua Li ¹Shun Yu ³Jia Liu ⁴Min Chen¹

作者信息

1. Laboratory of Neuroscience,Guangxi Neurological Diseases Clinical Research Center,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi Zhuang Autonomous Region,China Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guilin,Guangxi Zhuang Autonomous Region,China Guangxi Engineering Research Center of Digital Medicine and Clinical Translation,Guilin Medical University,Guilin,Guangxi Zhuang Autonomous Region,China
2. Laboratory of Neuroscience,Guangxi Neurological Diseases Clinical Research Center,Affiliated Hospital of Guilin Medical University,Guilin,Guangxi Zhuang Autonomous Region,China Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guilin,Guangxi Zhuang Autonomous Region,China
3. Department of Neurobiology,Xuanwu Hospital,Capital Medical University,Beijing,China
4. Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Capital Medical University,Beijing,China
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摘要

关键词

α-synuclein/dopaminergic neurodegeneration/internalization/low-density lipoprotein receptor-related protein 1/lysine/pre-formed fibril/movement disorder/nigrostriatal system/Parkinson''s disease/transmission

分类

医药卫生

引用本文复制引用

Hanjiang Luo,Caixia Peng,Chengli Wu,Chengwei Liu,Qinghua Li,Shun Yu,Jia Liu,Min Chen..Low-density lipoprotein receptor–related protein 1 mediatesα-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson's disease[J].Neural Regeneration Research,2026,21(4):P.1595-1606,12.

基金项目

supported by the Natural Science Foundation of Guangxi Zhuang Automomous Region,Nos.2019GXNSFDA245015(to MC),2022GXNSFBA035654(to HL) （to MC）

the National Natural Science Foundation of China,Nos.82360241(to MC),82304876(to HL) （to MC）

Scientific Research and Technology Development Project of Guilin City,Nos.20220139-3(to MC),20210218-5(to HL) （to MC）

Guangxi Medical and Health Key Discipline Construction Project(to QL)。（to QL）

Neural Regeneration Research

ISSN：1673-5374

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