磁共振成像2025，Vol.16Issue(6)：10-20,26,12.DOI:10.12015/issn.1674-8034.2025.06.002
三种降糖药对T2DM患者嗅觉神经环路重塑价值的fMRI研究
Investigation of the value of olfactory neural circuit remodeling in T2DM patients treated with three anti-diabetic drugs
摘要
Abstract
Objective:To investigate the effects of three commonly used anti-diabetic drugs-Liraglutide,Dapagliflozin,and Acarbose-on functional connectivity(FC)between olfactory vulnerable regions and the whole brain in patients with type 2 diabetes mellitus(T2DM).Materials and Methods:The study consists of two phases:baseline and drug treatment.In the baseline phase,51 normal controls and 191 T2DM patients were recruited to assess differences in FC,cognitive function,olfactory behavior,and clinical indicators between the two groups.In the drug treatment follow-up phase,36 T2DM patients with inadequate glycemic control despite metformin treatment were randomly assigned to three treatment groups:Liraglutide(n=12),Dapagliflozin(n=12),and Acarbose(n=12),for a 16-week period.A randomized controlled trial(RCT)was conducted to evaluate the effects of three drugs on FC,cognitive function,and olfactory behavior.Results:After 16 weeks of Liraglutide treatment,significant improvements in glycemic control and a notable reduction in body weight were observed in patients with T2DM.Delayed memory improved(t=-6.148,P<0.001)and olfactory thresholds increased(t=-2.321,P=0.040).The compensatory increase in FC between the left thalamus and left inferior occipital gyrus,as well as the right thalamus and left fusiform gyrus,was restored(Gaussian random field correction,voxel level P<0.005,cluster level P<0.05).No statistically significant differences were observed before and after treatment in the Acarbose and Dapagliflozin groups(P>0.05).Conclusions:This study demonstrates that Liraglutide significantly improves brain FC between the bilateral thalamus and left occipital lobe,cognitive function,and olfactory thresholds,suggesting neuroprotective effects beyond its metabolic benefits.In contrast,Dapagliflozin and Acarbose did not exhibit significant effects on olfactory,cognitive,or brain function protection.关键词
2型糖尿病/降糖药物/胰高血糖素样肽-1受体激动剂/功能连接/嗅觉神经环路/磁共振成像Key words
type 2 diabetes mellitus/anti-diabetic drugs/glucagon-like peptide-1 receptor agonists/functional connectivity/olfactory neural circuitry/magnetic resonance imaging分类
医药卫生引用本文复制引用
吴敏,毕艳,张冰,李欣,张雯,李卫萍,张易,李倩,申欣怡,张鑫,计成..三种降糖药对T2DM患者嗅觉神经环路重塑价值的fMRI研究[J].磁共振成像,2025,16(6):10-20,26,12.基金项目
National Natural Science Foundation of China(No.82330059,82271965). 国家自然科学基金项目(编号:82330059、82271965) （No.82330059,82271965）
