磁共振成像2025，Vol.16Issue(6)：21-26,6.DOI:10.12015/issn.1674-8034.2025.06.003
EC-T化疗后乳腺癌患者大脑局部一致性异常的静息态功能磁共振成像研究
Resting functional magnetic resonance imaging study of cerebral local consistency abnormality in patients with breast cancer after EC-T chemotherapy
摘要
Abstract
Objective:To explore the potential neural mechanism related to cognitive impairment in breast cancer patients treated with EC-T(E:epirubicin,C:cyclophosphamide,T:paclitaxel)chemotherapy using resting-state functional magnetic resonance imaging.Materials and Methods:Twenty-nine breast cancer patients who underwent standard EC-T sequential chemotherapy were included in the study.Cognitive function assessments and MRI examinations were conducted before and after postoperative chemotherapy.We compared the longitudinal changes of cognitive function and regional homogeneity(ReHo)of related brain regions in breast cancer patients before and after chemotherapy and analyzed the correlation.Results:Compared to before chemotherapy,breast cancer patients exhibited reduced scores in word learning,short-term delayed recall,long-term delayed recall,Color Block Connection Test-1,Color Block Connection Test-2,and the number backward task(P<0.05)after chemotherapy.Additionally,the ReHo values of the left anterior cingulate gyrus,left middle cingulate gyrus,right middle temporal gyrus,and left putamen decreased significantly(P<0.001).Partial correlation analysis revealed that the difference in ReHo values of the left anterior cingulate gyrus before and after chemotherapy was positively correlated with the differences in word learning scores(r=0.526,P<0.05).Conclusions:Chemotherapy can induce alterations in the local consistency of multiple brain regions in breast cancer patients,and can also result in cognitive impairment.The abnormal ReHo value of the left anterior cingulate gyrus can serve as a clinically meaningful imaging biomarker for monitoring cognitive function changes in breast cancer patients who have undergone chemotherapy.关键词
乳腺癌/化疗/认知功能损伤/磁共振成像,局部一致性Key words
breast cancer/chemotherapy/cognitive impairment/magnetic resonance imaging/regional homogeneity分类
医药卫生引用本文复制引用
冯伟,刘同辉,李国强,张华文,张明..EC-T化疗后乳腺癌患者大脑局部一致性异常的静息态功能磁共振成像研究[J].磁共振成像,2025,16(6):21-26,6.基金项目
Key R&D Plan Project of Xianyang City(No.L2022ZDYFSF026) （No.L2022ZDYFSF026）
Science and Technology Breakthrough Project of Zhongshan Nuclear Industry Group Co.,LTD(No.61230302) 咸阳市重点研发计划项目(编号:L2022ZDYFSF026) （No.61230302）
中陕核工业集团有限公司科技攻关项目(编号:61230302) （编号:61230302）
