磁共振成像2025，Vol.16Issue(6)：42-47,6.DOI:10.12015/issn.1674-8034.2025.06.006
震颤型帕金森病患者脑灰质体积的改变:一项基于体素的形态学测量研究
Changes in cerebral gray matter volume in patients with tremor-dominant Parkinson's disease:A voxel-based morphometry study
摘要
Abstract
Objective:To apply voxel-based morphometry(VBM)to investigate the changes in gray matter volume(GMV)in the brains of patients with tremor-dominant Parkinson's disease(TD-PD).Materials and Methods:Three-dimensional T1-weighted imaging scans were performed on 22 randomly selected TD-PD patients and 22 age-and gender-matched healthy control(HC).Voxel-based morphometry(VBM)analysis was conducted on the three-dimensional structural images using SPM12 to detect gray matter volume.Results:Compared with the HC group,the gray matter volume of the right middle temporal gyrus(Temporal_Mid_L,MTG.R),the left superior orbitofrontal gyrus(Frontal_Mid_Orb_R,ORBsupmed.L),and the left calcarine cortex(Calcarine_L,CAL.L)were all reduced in the TD-PD group(FWE correction,cluster level P<0.001).The gray matter volume of the above-mentioned brain regions was negatively correlated with the tremor score(disease severity)of PD patients(r=-0.491,-0.512,-0.522,all P<0.05).Conclusions:The tremor symptoms of PD patients are related to visual information processing disorders and the decline in spatial perception ability,which leads to the deterioration of autonomous motor functions.Moreover,as the severity of clinical tremor symptoms in PD patients increases,the degree of structural damage in the related brain regions also further worsens.关键词
帕金森病/震颤/磁共振成像/基于体素的形态学测量/颞中回/眶内额上回/距状裂周围皮层Key words
Parkinson's disease/tremor/magnetic resonance imaging/voxel-based morphometry/middle temporal gyrus/medial orbital frontal gyrus/pericalcarine cortex分类
医药卫生引用本文复制引用
张佳文,胡涛,赵贝贝,林碧霞,崔晓峰,黄汝成,冯泽慧,江杨..震颤型帕金森病患者脑灰质体积的改变:一项基于体素的形态学测量研究[J].磁共振成像,2025,16(6):42-47,6.基金项目
Shenzhen Bao'an District Medical and Health Research Project(No.2023JD086) （No.2023JD086）
Special Project on Traditional Chinese Medicine Research for the Acupuncture Treatment of Common,Frequent,and Major Diseases(No.2022KJCX-ZJZL-6). 深圳市宝安区医疗卫生科研项目(编号:2023JD086) （No.2022KJCX-ZJZL-6）
针灸治疗常见病、多发病、重大疾病的中医药研究专项(编号:2022KJCX-ZJZL-6) （编号:2022KJCX-ZJZL-6）
