磁共振成像2025，Vol.16Issue(6)：48-54,7.DOI:10.12015/issn.1674-8034.2025.06.007
脑小血管病伴与不伴认知功能障碍患者脑功能局部一致性差异研究
A study on differences of regional homogeneity on brain function between cerebral small vessel disease patients with and without cognitive impairment
摘要
Abstract
Objective:To explore the differences of regional homogeneity on brain function and their correlations with cognitive assessments in cerebral small vessel disease(CSVD)patients with and without cognitive impairment and healthy controls(HC).Materials and Methods:A retrospective analysis was conducted on the demographic characteristics of 33 CSVD patients with mild cognitive impairment(CSVD-m),32 CSVD patients with no cognitive impairment(CSVD-n),and 30 gender-,age-,education-matched healthy controls(HC).The cognitive function of all subjects was evaluated using a series of cognitive assessments.T1-weighted structural magnetic resonance imaging data and resting-state functional magnetic resonance imaging data of all subjects were collected,and the regional homogeneity(ReHo)values of 170 brain regions in the automated anatomical labeling(AAL)template were calculated.The differences of ReHo values among the three groups and the relationships between ReHo values in altered brain regions and cognitive assessments were analyzed.Results:Compared with the HC group,the CSVD-m group and CSVD-n group had abnormal areas in the default mode network,subcortical network,sensorimotor network,and visual network(GRF correction,voxel-level P<0.001,cluster-level P<0.05).Compared with the CSVD-n group,the CSVD-m group had abnormal areas in the visual network(GRF correction,voxel-level P<0.001,cluster-level P<0.05).In the CSVD-m group,the ReHo values of the left caudate(r=0.453,P=0.008)and right middle cingulum(r=0.349,P=0.046)were positively correlated with the trail making test B;the ReHo values of the right insula were positively correlated with the auditory verbal learning test-delayed recall(r=0.386,P=0.027);the ReHo values of the left Rolandic operculum(r=-0.348,P=0.047)and lingual gyrus(r=-0.372,P=0.033)were negatively correlated with the Rey-Osterrieth complex figure test-immediate recall;the ReHo values of the left postcentral gyrus were negatively correlated with the Stroop Ⅰ test(r=-0.347,P=0.048).Conclusions:CSVD patients exhibit abnormal regional homogeneity across multiple brain regions,most notably in the right middle cingulum and insula,as well as the left caudate,Rolandic operculum,postcentral gyrus,and lingual gyrus.These alterations are closely associated with cognitive functions such as attention,executive function,and memory.These findings may reflect the neuropathophysiological basis of CSVD-related cognitive impairment and hold potential value as early neuroimaging markers for its identification.关键词
脑血管疾病/认知障碍/磁共振成像/局部一致性/脑网络Key words
cerebrovascular disorders/cognitive impairment/magnetic resonance imaging/regional homogeneity/brain network分类
医药卫生引用本文复制引用
王文雯,黄晶,程润田,刘筱霜,罗天友..脑小血管病伴与不伴认知功能障碍患者脑功能局部一致性差异研究[J].磁共振成像,2025,16(6):48-54,7.基金项目
Chongqing Science and Technology Innovation Leading Talent Support Program(No.cstc2022ycjh-bgzXM0230). 重庆英才计划项目(编号:cstc2022ycjh-bgzXM0230) （No.cstc2022ycjh-bgzXM0230）
