磁共振成像2025，Vol.16Issue(6)：55-59,65,6.DOI:10.12015/issn.1674-8034.2025.06.008
基于MRI 3D-FLAIR序列对终末期肾病患者脑白质高信号病变特征与临床指标相关性研究
A study investigating the correlation between white matter hyperintensities lesion characteristics in end-stage renal disease patients and clinical indicators using MRI 3D-FLAIR
摘要
Abstract
Objective:To investigate the volume and distribution characteristics of white matter hyperintensities(WMH)in patients with end-stage renal disease(ESRD)using MRI three dimensional-fluid attenuated inversion recovery(3D-FLAIR),and to determine if specific brain regions are more susceptible to lesion development and to assess the relationship between WMH volume and clinical biochemical markers and cognitive function.Materials and Methods:MRI image data and clinical biochemical indices from 81 ESRD patients and 77 healthy controls were collected.CAT12 software was used to analyze 3D-T1WI images to obtain the whole brain volume of each subject.The 3D-FLAIR images were analyzed by Lesion Prediction Algorithm(LPA)in Lesion Segmentation Tool(LST)to obtain the volume and distribution map of WMH.Two-sample t-test and Mann-Whitney U test were used to analyze the differences in cognitive function scores and the severity of WMH(the ratio of WMH to total brain volume)between the two groups.The Liebermeister test in non-parametric mapping(NPM)software was employed to compare the distribution maps between the two groups.After controlling for the effects of age and gender using partial correlation analysis,the correlations between the severity of WMH and both clinical biochemical indicators as well as cognitive function were assessed.Furthermore,the two groups were categorized according to the severity of WMH,and the ROC curve was constructed.Results:The cognitive function scores of the ESRD group were significantly lower compared to the control group[Montreal Cognitive Assessment(MoCA):22.44±5.23 vs.26.06±3.20,P<0.001;Mini-Mental State Examination(MMSE):25.96±3.81 vs.28.61±1.85,P<0.001].The severity of WMH in the ESRD group was significantly higher than in the control group[1.40(2.60)vs.0.36(0.40),P<0.001].The proportion of WMH in the ESRD group was also higher(Z:1.914 to 6.483,P<0.05).Although WMH severity was not associated with cognitive function(P>0.05),it was negatively correlated with serum albumin and glomerular filtration rate(r=-0.337,P=0.002;r=-0.231,P=0.041).The area under the ROC curve was 0.817(95%CI:0.751 to 0.884).Conclusions:Periventricular white matter is particularly vulnerable to damage in ESRD patients,which is closely linked to the decline in renal function and serum albumin levels.WMH serves as a significant imaging marker for effectively distinguishing white matter damage in ESRD.关键词
终末期肾脏病/磁共振成像/脑白质高信号Key words
end-stage renal disease/white matter hyperintensities/magnetic resonance imaging分类
医药卫生引用本文复制引用
邹帆,王海宝,方杰,齐向明,周宇,李晓舒..基于MRI 3D-FLAIR序列对终末期肾病患者脑白质高信号病变特征与临床指标相关性研究[J].磁共振成像,2025,16(6):55-59,65,6.基金项目
Natural Science Foundation of Anhui Province(No.1908085MH245) （No.1908085MH245）
Natural Science Research Project of Anhui Universities(No.KJ2018A0493). 安徽省自然科学基金项目(编号:1908085MH245) （No.KJ2018A0493）
安徽高校自然科学研究项目(编号:KJ2018A0493) （编号:KJ2018A0493）
