磁共振成像2025，Vol.16Issue(6)：60-65,6.DOI:10.12015/issn.1674-8034.2025.06.009
基于远程功能连接密度的额颞叶变性患者脑白质功能的研究
Study of white matter function in patients with frontotemporal dementia based on long-ranges functional connectivity density
摘要
Abstract
Objective:This study employed long-range functional connectivity density(lr-FCD)to assess resting-state functional alterations in the white matter of patients with frontotemporal dementia(FTD).Materials and Methods:A total of 31 healthy controls(HC)and 30 FTD patients were included from the Image and Data Archive(IDA).All participants underwent high-resolution T1-weighted structural imaging and resting-state functional magnetic resonance imaging(rs-fMRI).The T1 structural images were segmented into gray matter,white matter,and cerebrospinal fluid,and a group-level white matter mask was generated.The rs-fMRI data were preprocessed,and the lr-FCD metric was calculated based on the white matter mask.A one-sample t-test was used to examine the distribution of lr-FCD in both HC and FTD groups,followed by a two-sample t-test to compare intergroup differences in lr-FCD.Results:Significant differences were observed in educational attainment between the FTD and HC groups(P<0.05,t=3.232).The clinical dementia rating score of the FTD group was(1.200±0.407).The Mini-Mental State Examination(MMSE)scores were(29.500±0.626)for the HC group and(23.100±4.140)for the FTD group,showing a statistically significant difference(P<0.001,t=3.460).In the HC group,high lr-FCD values were primarily located in the posterior thalamic radiation(including the optic radiation),whereas in the FTD group,they were predominantly found in the posterior corona radiata.Compared with the HC group,the FTD group exhibited significantly increased lr-FCD in the posterior corona radiata and superior longitudinal fasciculus.Conclusions:The findings suggest that the neuropathological mechanism of FTD may be associated with abnormal long-range functional connectivity in white matter.关键词
额颞叶变性/功能连接密度/静息态功能磁共振成像/磁共振成像/白质/病理机制Key words
frontotemporal dementia/functional connectivity density/resting-state functional magnetic resonance imaging/magnetic resonance imaging/white matter/pathological mechanism分类
医药卫生引用本文复制引用
魏伟,樊丽华,田欣,郑运松,周锋..基于远程功能连接密度的额颞叶变性患者脑白质功能的研究[J].磁共振成像,2025,16(6):60-65,6.基金项目
Key Research and Development Plan Project of Shaanxi Province in 2024(No.2024SF-YBXM-524) （No.2024SF-YBXM-524）
Qin Chuangyuan Traditional Chinese Medicine Industry Innovation Cluster Project(No.L2024-QCY-ZYYJJQ-Y07,Y12) （No.L2024-QCY-ZYYJJQ-Y07,Y12）
Shaanxi Chinese Medicine Science and Technology Innovation Team-Brain cognitive disorders"needle and drug co-modulation"innovation team Program. 2024年度陕西省重点研发计划项目(编号:2024SF-YBXM-524) （编号:2024SF-YBXM-524）
秦创原中医药产业创新聚集区项目(编号:L2024-QCY-ZYYJJQ-Y07、Y12) （编号:L2024-QCY-ZYYJJQ-Y07、Y12）
陕西中医药学科技创新团队-脑认知障碍"针药共调"创新团队项目 （）
