分析测试学报2025，Vol.44Issue(7)：1282-1289,8.DOI:10.12452/j.fxcsxb.25011534
SinCHERS-TC/超高效液相色谱-串联质谱法测定动物源性食品中51种药物残留
Determination of 51 Drug Residues in Animal-derived Foods by SinCHERS-TC/Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry
摘要
Abstract
A method for the simultaneous determination of 51 veterinary drugs in animal-derived foods was establised by SinCHERS-TC/ultra-high performance liquid chromatography-tandem mass spectrometry(SinCHERS-TC/UPLC-MS/MS).Weigh 2 g of the samples and extract it with a mixed solution of acidified acetonitrile and Mcllvaine-Na2 EDTA buffer.The extract was filtered through a purification tube with the help of squeezing apparatus.The filtrate was diluted with water with a ratio of 1∶1 and then tested by ultra-high performance liquid chromatography-tandem mass spectrometry.Matrix-matched external standard method was used for quantification.The results showed that the lin-ear relationships of the 51 drugs were good in the range of 0.5-10.0 μg/L,and the correlation coeffi-cients(r2)were not less than 0.999 0.The detection limits(LODs)of 51 drugs were between 4 μg/kg and 10 μg/kg,and the quantification limits(LOQs)were between 8 μg/kg and 20 μg/kg.With beef as the substrate,the average recoveries were between 82.8%and 109%at spiked levels of LOQ,2LOQ and 10LOQ,and the relative standard deviations(RSDs,n=6)were between 0.30%and 8.0%.This method is simple in pretreatment,convenient and efficient in operation,and is charac-terized by high sensitivity and good accuracy.It is suitable for batch screening and detection of 51 drug residues in chicken,pork,beef,mutton and fish.关键词
SinCHERS-TC/超高效液相色谱-串联质谱/动物源性食品/药物残留Key words
SinCHERS-TC/ultra-high performance liquid chromatography-tandem mass spec-trometry/animal-derived foods/drug residues分类
化学化工引用本文复制引用
文英会,张崇威,刘占通,张辉鹏,王坤丽,陈红英..SinCHERS-TC/超高效液相色谱-串联质谱法测定动物源性食品中51种药物残留[J].分析测试学报,2025,44(7):1282-1289,8.基金项目
国家重点研发项目(2022YFD1601606) （2022YFD1601606）
