分析化学2025，Vol.53Issue(6)：875-884,10.DOI:10.19756/j.issn.0253-3820.251044
提升离子迁移谱性能的低迁移率歧视Bradbury-Nielsen门控方法研究
Improvement of Performance of Ion Mobility Spectrometry Using A Low Discrimination Bradbury-Nielsen Gate Controlling Method
摘要
Abstract
The resolving power and sensitivity are critical for on-site detection of hazardous chemicals using stand-alone ion mobility spectrometry(IMS).However,improving the sensitivity and resolving power of IMS has long been a prominent research hot spot.In the commonly used IMS based on the Bradbury-Nielsen gate(BNG),the gating voltage difference(GVD)applied between the two sets of grid wires affects the electric field distribution in the ionization region and the drift region.This,in turn,influences the spatial distribution and temporal width of the injected ion swarm,and has an impact on the ion mobility discrimination,sensitivity,and resolving power of the instrument.This study showed that increasing the GVD could induce an ion converging effect,boosting the ion number density in front of the BNG by nearly 300％.To simultaneously utilize temporal compression and ion converging effects,a novel BNG controlling mode was proposed by adding a chopping state to the conventional controlling mode.This chopping state reduced the mobility discrimination effects between ions with mobility differences up to about 0.90 cm2/(V·s)to 1/22 of their original value.When analyzing hazardous chemical mixtures using the novel BNG controlling mode,compared with conventional mode,the signal intensity of low-mobility methyl salicylate ions(MS·O2)-increased by 18-fold while the resolving power maintained around 100,and the detection limit for MS was improved from 3.75 μg/L to 97 ng/L.This novel BNG controlling mode only added a potential wave to the low voltage wires,with no requirement of changing the structure of the drift tube,and was easy to apply to existing commercial instruments.关键词
离子迁移谱/Bradbury-Nielsen型离子门/迁移率歧视/离子团时域压缩/离子汇聚效应Key words
Ion mobility spectrometry/Bradbury-Nielsen gate/Ion mobility discrimination/Temporal compression/Ion converging effect引用本文复制引用
杨其穆,徐一仟,潘慢慢,蒋丹丹,陈创,李海洋..提升离子迁移谱性能的低迁移率歧视Bradbury-Nielsen门控方法研究[J].分析化学,2025,53(6):875-884,10.基金项目
国家自然科学基金项目(Nos.22027804,21974141)、大连市科技人才创新支持计划项目(No.2024RY022)和中国科学院大连化学物理研究所创新研究基金项目(Nos.DICP I202422,DICP I202442)资助. Supported by the National Natural Science Foundation of China(Nos.22027804,21974141),the Dalian High-Level Talent Innovation Support Project(No.2024RY022),and the Dalian Institute of Chemical Physics,Chinese Academy of Sciences(Nos.DICP I202422,DICP I202442). （Nos.22027804,21974141）
