感染、炎症、修复2025，Vol.26Issue(3)：145-148,4.DOI:10.3969/j.issn.1672-8521.2025.03.001
慢性创面中细胞衰老和治疗策略的再认识
Re-understanding of cellular senescence and therapeutic strategies in chronic wounds
摘要
Abstract
Chronic wounds(e.g.,diabetic foot ulcers,venous ulcers and pressure injuries)have emerged as a significant public health concern,characterized by complex pathogenesis and limited therapeutic efficacy.Recent studies demonstrate that cellular senescence plays a pivotal role in non-healing processes where senescent cells continuously secrete senescence-associated secretory phenotype factors,triggering a"senescence cascade"that disrupts the wound microenvironment.In the context of diabetes,advanced age and venous return disorder,keratinocytes,fibroblasts and immune cells can undergo senescence,leading to persistent inflammation and impaired tissue remodeling.Targeting this mechanism,senolytic drugs to eliminate senescent cells and mesenchymal stem cell therapy to rejuvenate the senescent microenvironment have emerged as key research focuses.Fetal dermal mesenchymal stem cells exhibit unique advantages in senescence delay,immune regulation and wound healing promotion.This review explores the pathological mechanisms of cellular senescence in chronic wounds,current intervention strategies and clinical translation prospects,highlighting the combining senescence-targeted interventions with regenerative technologies to advance precision therapies for chronic wounds.关键词
创面愈合/炎症微环境/慢性创面/细胞衰老/间充质干细胞Key words
Wound healing/Inflammatory microenvironment/Chronic wound/Cellular senescence/Mesenchymal stem cells分类
医药卫生引用本文复制引用
姜笃银,陆美琪..慢性创面中细胞衰老和治疗策略的再认识[J].感染、炎症、修复,2025,26(3):145-148,4.基金项目
国家自然科学基金资助项目(81873934) （81873934）
王正国创伤医学发展基金会(SZYZ-TR-09) （SZYZ-TR-09）
山东省科技攻关项目(2019GGX10501) （2019GGX10501）
山东大学临床研究项目(2021SDUCRCA008) （2021SDUCRCA008）
济南市科技计划项目(202225065) （202225065）
