基于近红外碳点的"开-关-开"型盐酸氯丙嗪荧光传感器的构建
Construction and Application of"On-Off-On"Fluorescence Sensor for Chlorpromazine Hydrochloride Based on Near Infrared Carbon Quantum Dots
摘要
Abstract
In this work,near infrared carbon quantum dots(NIR-CDs)were synthesized by hydrothermal method using biomass material Clausena lansium leaves.The synthesized NIR-CDs emitted maximum fluorescence signal at 677 nm,which was independent of excitation wavelength.The characterization results showed that there were abundant groups on the surface of NIR-CDs.Pd2+could form non-fluorescent compounds with the surface groups of NIR-CDs,resulting in fluorescence quenching(Fluorescence signal was denoted as F0).Because chlorpromazine hydrochloride(CPZ)parent nucleus contained unoxidized S atom,CPZ could form stable colored complex with Pd2+under acidic conditions.In the presence of CPZ,Pd2+dissociated from the surface of NIR-CDs and bonded with CPZ,so that the fluorescence signal could be restored(Fluorescence signal was denoted as F).An"on-off-on"fluorescence sensor was thus constructed.The fluorescence signal recovery value of NIR-CDs(△F=F-F0)showed a good linear relationship with the concentration of CPZ in the range of 5.68-28.43 μg/mL,and the detection limit(3σ)was 0.078 μg/mL.The sensor was applied to determination of CPZ in pharmaceutical preparations,and the recoveries were 94％-106％.The developed fluorescence sensor was expected to be used in quality control of actual pharmaceutical preparations.关键词
近红外碳点/荧光传感器/钯离子/盐酸氯丙嗪Key words
Near infrared carbon quantum dots/Fluorescence sensor/Palladium ion/Chlorpromazine hydrochloride引用本文复制引用
林瑜,谭凤,申玉华,朱丽琴,严佩瑶,潘金桃,刘凯顺..基于近红外碳点的"开-关-开"型盐酸氯丙嗪荧光传感器的构建[J].分析化学,2025,53(6):934-943,10.基金项目
广西中医药大学引进博士科研启动基金项目(No.2023BS015)、广西壮族自治区高校黄大年式教师团队"中药学传承创新教师团队"项目(No.桂教教师[2023]31号)、广西中医药大学大学生科研训练课题项目(No.2023DXS08)、广西壮族自治区大学生创新训练项目(No.202410600030)和广西中医药大学大学生创新训练项目(No.X202410600130)资助. Supported by the Guangxi University of Chinese Medicine Introduced the Doctoral Research Start-up Fund Project(No.2023BS015),the Huang Danian Teaching Team of Universities in Guangxi Zhuang Autonomous Region"Traditional Chinese Medicine Inheritance Innovation Teacher Team"(No.GUI Teacher[2023]31),the Research Training Project of Guangxi University of Chinese Medicine(No.2023DXS08),the Innovative Training Project of Guangxi Zhuang Autonomous Region College Students Project(No.202410600030),and the Guangxi University of Chinese Medicine Student Innovation Training Project(No.X202410600130). （No.2023BS015）
