广西医学2025，Vol.47Issue(5)：651-658,8.DOI:10.11675/j.issn.0253-4304.2025.05.03
2型炎症性皮肤病的发病机制和治疗进展
Pathogenesis and treatment progress on type 2 inflammatory skin disease
摘要
Abstract
Type 2 inflammatory response is an inflammatory process driven by the combined action of Th2,type 2 innate lymphoid cell,and type Th2 cytokines.Type Th2 cytokines include interleukin(IL)-4,IL-5,IL-9,IL-13,and IL-31,primarily secreted by immune cells,as well as IL-25,IL-33,and thymic stromal lymphopoietin,mainly produced by tissue cells,particularly epithelial cells.With ongoing research into the pathogenesis of type 2 inflammatory response,it has been implicated that abnormal type 2 inflammatory response participated in various skin diseases characterized by chronic tissue inflammation.In recent years,treatment strategies of inhibiting type 2 inflammatory response have continued to evolve,including biologics of target cytokines or their receptors,as well as Janus kinase inhibitors of blocking intracellular cytokine signaling pathways.This paper summarizes progress on the pathogenesis and treatment strategies of type 2 inflammatory skin diseases.关键词
2型炎症性皮肤病/发病机制/治疗/进展Key words
Type 2 inflammatory skin diseases/Pathogenesis/Treatment/Progress分类
医药卫生引用本文复制引用
李秋菊,林有坤,郑文军,张建中..2型炎症性皮肤病的发病机制和治疗进展[J].广西医学,2025,47(5):651-658,8.基金项目
广西自然科学青年科学基金(区域高发疾病研究联合专项)(2024GXNSFBA010069) （区域高发疾病研究联合专项）
